RPGRIP1 and RPGR

Number of citations of the paper that reports this interaction (PubMedID 27173435)
70

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		RPGRIP1	RPGR
Description		RPGR interacting protein 1	retinitis pigmentosa GTPase regulator
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Microtubule Cytoskeleton Photoreceptor Connecting Cilium Cell Projection Neuron Projection Intercellular Bridge Non-motile Cilium Photoreceptor Distal Connecting Cilium	Photoreceptor Outer Segment Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Photoreceptor Cell Cilium
	Molecular Function	Protein Binding	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Visual Perception Eye Photoreceptor Cell Development Retinal Rod Cell Development Retina Development In Camera-type Eye Neural Precursor Cell Proliferation Non-motile Cilium Assembly	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Visual Perception Positive Regulation Of Autophagy Protein Ubiquitination Cell Projection Organization Intraciliary Transport Eye Photoreceptor Cell Development Cilium Organization Cilium Assembly Protein Localization To Non-motile Cilium
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	15 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RNF10 RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE
Entrez ID		57096	6103
HPRD ID		05673	02425
Ensembl ID		ENSG00000092200	ENSG00000156313
Uniprot IDs		Q96KN7	A0A2R8YFT6 Q92834
PDB IDs		4QAM	4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleus Regulation Of RNA Biosynthetic Process Ciliary Basal Body	Cilium Microtubule-based Process Centrosome Microtubule Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Cilium Organization Organelle Assembly Mitotic Spindle Organization Establishment Of Meiotic Sister Chromatid Cohesion Kinesin II Complex Non-motile Cilium Establishment Of Vesicle Localization Microtubule Cytoskeleton Organization Vesicle Localization Cilium Assembly Establishment Of Organelle Localization Meiotic Cohesin Complex Mediator Complex Binding Spindle Microtubule Cytoskeleton Plus-end-directed Vesicle Transport Along Microtubule Ciliary Tip Establishment Of Localization In Cell Condensed Nuclear Chromosome Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Plus-end-directed Organelle Transport Along Microtubule Non-motile Cilium Assembly Organelle Organization Centriole Spindle Organization Establishment Of Sister Chromatid Cohesion Transport Along Microtubule Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Microtubule Anchoring At Centrosome Cytoskeleton-dependent Intracellular Transport Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Microtubule-based Transport Axo-dendritic Transport Organelle Localization Intercellular Bridge Protein Phosphatase Binding Mitotic Sister Chromatid Cohesion Intracellular Transport Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?