STING1 and IFI16

Number of citations of the paper that reports this interaction (PubMedID 31665637)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		STING1	IFI16
Description		stimulator of interferon response cGAMP interactor 1	interferon gamma inducible protein 16
Image
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex STING Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Binding Proton Channel Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine/threonine Kinase Binding	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Monoatomic Ion Transport Autophagy Regulation Of Gene Expression Positive Regulation Of Macroautophagy Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interferon-beta Production Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Protein Complex Oligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Reticulophagy Protein Localization To Endoplasmic Reticulum Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Immune System Process Autophagy Apoptotic Process Inflammatory Response Regulation Of Autophagy Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Cellular Response To Interferon-beta Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of AIM2 Inflammasome Complex Assembly
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS			C-reactive protein ( 22939635) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte percentage of white cells ( 32888494) Neutrophil count in HIV-infection ( 25884002) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		26 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM10 USP20 USP35 USP49 YIPF2	13 interacting genes: APP AR AURKA BRCA1 CEBPA CSNK2A1 ID1 ID2 ID3 STING1 TP53 TP53BP1 TPR
Entrez ID		340061	3428
HPRD ID		14173	00969
Ensembl ID		ENSG00000184584	ENSG00000163565
Uniprot IDs		A0A494C0W5 J3QTB1 Q86WV6 V5V0K2	Q16666
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP 6Y99 6YDB 6YDZ 6YEA 6YWA 6YWB 6Z0Z 6Z15 7A90 7KVX 7KVZ 7KW1 7MHC 7OB3 7Q3B 7Q85 7R4H 7SHO 7SHP 7SII 7SSM 7T9U 7T9V 7X9P 7X9Q 7ZKU 7ZV0 7ZVK 7ZWL 7ZXB 8A2H 8A2I 8A2J 8A2K 8A2X 8B2J 8FLK 8FLM 8GJX 8GSZ 8GT6 8IK3 8ORW 8P45 8STH 8STI 8T5K 8T5L 9IJN	2OQ0 3B6Y 3RLN 3RLO 3RNU 4QGU 8X70
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex Post-translational Protein Modification Protein Modification Process Early Endosome To Golgi Transport Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein N-linked Glycosylation Via Asparagine	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Developmental Process Intracellular Signal Transduction DNA Damage Checkpoint Signaling Molecular Function Activator Activity Rhythmic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Circadian Rhythm Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Transcription Regulator Inhibitor Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation
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