TMEM173 and DDOST

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		TMEM173	DDOST
Gene Name		transmembrane protein 173	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Positive Regulation Of Transcription Factor Import Into Nucleus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Exogenous DsRNA	Translation Protein Glycosylation Protein N-linked Glycosylation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Cytokine T Cell Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response
Pathways		Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Translation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 SRP-dependent cotranslational protein targeting to membrane Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		9 interactors: CCDC47 DDOST IRAK1 LTN1 MBOAT7 SGPL1 STT3A SURF4 TRIM32	4 interactors: MAPK6 NXT1 SRSF11 TMEM173
Entrez ID		340061	1650
HPRD ID		14173	03728
Ensembl ID			ENSG00000244038
Uniprot IDs		Q86WV6	E7EWT1 P39656
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI
Enriched GO Terms of Interacting Partners?			RNA Export From Nucleus Nuclear Export RNA Transport RNA Localization Interferon-beta Production Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Cytoplasmic Transport Regulation Of Defense Response To Virus By Host Cellular Response To DsRNA Protein Export From Nucleus Positive Regulation Of Transcription Factor Import Into Nucleus Termination Of RNA Polymerase II Transcription
Tagcloud ?		advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish	3xflag atp5c1 compatible created creating deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish	3xflag atp5c1 compatible created creating deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?