STING1 and MBOAT7

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		STING1	MBOAT7
Description		stimulator of interferon response cGAMP interactor 1	membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex STING Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Binding Proton Channel Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine/threonine Kinase Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Lysophospholipid Acyltransferase Activity
	Biological Process	Autophagosome Assembly Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Monoatomic Ion Transport Autophagy Regulation Of Gene Expression Positive Regulation Of Macroautophagy Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interferon-beta Production Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Protein Complex Oligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Reticulophagy Protein Localization To Endoplasmic Reticulum Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Proton Transmembrane Transport	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process Ventricular System Development Layer Formation In Cerebral Cortex Lipid Modification Phosphatidylinositol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylinositol Metabolic Process Regulation Of Triglyceride Metabolic Process
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Acyl chain remodelling of PI
Drugs
Diseases
GWAS			Cirrhosis (alcohol related) ( 26482880 32853455) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)
Interacting Genes		26 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM10 USP20 USP35 USP49 YIPF2	8 interacting genes: ADRA1A BDKRB1 FNDC3B MAPK6 SHANK3 STING1 UBC UNC93B1
Entrez ID		340061	79143
HPRD ID		14173	06925
Ensembl ID		ENSG00000184584	ENSG00000125505
Uniprot IDs		A0A494C0W5 J3QTB1 Q86WV6 V5V0K2	Q96N66
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP 6Y99 6YDB 6YDZ 6YEA 6YWA 6YWB 6Z0Z 6Z15 7A90 7KVX 7KVZ 7KW1 7MHC 7OB3 7Q3B 7Q85 7R4H 7SHO 7SHP 7SII 7SSM 7T9U 7T9V 7X9P 7X9Q 7ZKU 7ZV0 7ZVK 7ZWL 7ZXB 8A2H 8A2I 8A2J 8A2K 8A2X 8B2J 8FLK 8FLM 8GJX 8GSZ 8GT6 8IK3 8ORW 8P45 8STH 8STI 8T5K 8T5L 9IJN	8ERC
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex Post-translational Protein Modification Protein Modification Process Early Endosome To Golgi Transport Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein N-linked Glycosylation Via Asparagine	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Intracellular Signal Transduction Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure MAPK Cascade Bradykinin Receptor Activity Regulation Of Dendritic Spine Development Septin Cytoskeleton Positive Regulation Of Dendritic Spine Development Cytoplasmic Pattern Recognition Receptor Signaling Pathway Guanylate Kinase-associated Protein Clustering Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Neuron-glial Cell Signaling Positive Regulation Of Synaptic Transmission T Cell Antigen Processing And Presentation Toll-like Receptor 7 Signaling Pathway Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Cardiac Muscle Contraction Signal Transduction Regulation Of Blood Pressure Regulation Of The Force Of Heart Contraction By Chemical Signal Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Mitochondrial Outer Membrane Innate Immune Response-activating Signaling Pathway Toll-like Receptor Binding Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Vocal Learning Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Observational Learning Proton Channel Activity Positive Regulation Of CGAS/STING Signaling Pathway
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