STING1 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 28763789)
37

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		STING1	MUL1
Description		stimulator of interferon response cGAMP interactor 1	mitochondrial E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex STING Complex	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane Axon Neuronal Cell Body
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Binding Proton Channel Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine/threonine Kinase Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Monoatomic Ion Transport Autophagy Regulation Of Gene Expression Positive Regulation Of Macroautophagy Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interferon-beta Production Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Protein Complex Oligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Reticulophagy Protein Localization To Endoplasmic Reticulum Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Proton Transmembrane Transport	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Positive Regulation Of Developmental Process Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Type 2 Mitophagy
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		26 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM10 USP20 USP35 USP49 YIPF2	34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1
Entrez ID		340061	79594
HPRD ID		14173	07799
Ensembl ID		ENSG00000184584	ENSG00000090432
Uniprot IDs		A0A494C0W5 J3QTB1 Q86WV6 V5V0K2	Q969V5
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP 6Y99 6YDB 6YDZ 6YEA 6YWA 6YWB 6Z0Z 6Z15 7A90 7KVX 7KVZ 7KW1 7MHC 7OB3 7Q3B 7Q85 7R4H 7SHO 7SHP 7SII 7SSM 7T9U 7T9V 7X9P 7X9Q 7ZKU 7ZV0 7ZVK 7ZWL 7ZXB 8A2H 8A2I 8A2J 8A2K 8A2X 8B2J 8FLK 8FLM 8GJX 8GSZ 8GT6 8IK3 8ORW 8P45 8STH 8STI 8T5K 8T5L 9IJN	6K2K 6M2C 6M2D
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex Post-translational Protein Modification Protein Modification Process Early Endosome To Golgi Transport Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein N-linked Glycosylation Via Asparagine	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Ubiquitin-protein Transferase Activity Proteolysis Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Nucleotide Binding ATP Binding Protein K11-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Transferase Activity Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Regulation Of Macroautophagy ISG15-protein Conjugation Cellular Response To Interferon-beta DNA Damage Response Protein K63-linked Ubiquitination Response To Interferon-beta Cellular Response To Stress Cytosol Response To Stress DNA Repair Positive Regulation Of Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Autophagy Nucleoplasm TORC1 Signaling Negative Regulation Of TORC1 Signaling Apoptotic Mitochondrial Changes DNA Metabolic Process Cellular Response To Nutrient Levels UBC13-MMS2 Complex Protein K6-linked Ubiquitination CGAS/STING Signaling Pathway TOR Signaling Ubiquitin Conjugating Enzyme Complex
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