MCC and RASAL2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MCC	RASAL2
Description		MCC regulator of Wnt signaling pathway	RAS protein activator like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection	Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Response To Dietary Excess Signal Transduction Response To Glucose Gene Expression Multicellular Organism Growth Adipose Tissue Development Regulation Of Intracellular Signal Transduction Regulation Of Protein Activation Cascade
Pathways			Regulation of RAS by GAPs RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 28115744) Body mass index ( 19079260 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Immune response to smallpox vaccine (IL-6) ( 22542470) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Weight ( 19079260)
Interacting Genes		77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	10 interacting genes: HMGB1 MCC MEOX2 MIA2 NFKBIB SYNJ1 TRAF1 UBC USHBP1 YWHAG
Entrez ID		4163	9462
HPRD ID		01157	05845
Ensembl ID		ENSG00000171444	ENSG00000075391
Uniprot IDs		P23508	A0A8Q3SIU1 A0A8Q3SJF6 A8K2P3 Q9UJF2
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome	Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell
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