MCC and TRMO

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MCC	TRMO
Description		MCC regulator of Wnt signaling pathway	tRNA methyltransferase O
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Methyltransferase Activity Transferase Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	TRNA Processing TRNA Methylation Methylation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Orofacial clefts ( 33137956)
Interacting Genes		77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	22 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L STAC STK11 TGFBR2
Entrez ID		4163	51531
HPRD ID		01157	12945
Ensembl ID		ENSG00000171444	ENSG00000136932
Uniprot IDs		P23508	Q5T114 Q9BU70
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome	Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Kinase Activity Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Growth Kinase Activity Heart Valve Morphogenesis Regulation Of Phosphorylation Regulation Of Cell Differentiation Heart Development Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cell Population Proliferation Regulation Of Signal Transduction Endocardial Cushion Morphogenesis Nucleotide Binding Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Development Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process MutLalpha Complex Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Phosphorylation Ruffle Membrane Negative Regulation Of Growth Apoptotic Process Regulation Of Cell Growth Tricuspid Valve Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Programmed Cell Death Cytosol Cell Death Aortic Valve Morphogenesis Regulation Of Cell Cycle Phase Transition Mismatch Repair Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Cycle Process
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