MCC and GTF2E2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MCC	GTF2E2
Gene Name		mutated in colorectal cancers	general transcription factor IIE, polypeptide 2, beta 34kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Lamellipodium	Nucleus Nucleoplasm Transcription Factor TFIIE Complex Cytoplasm
	Molecular Function	Receptor Activity Protein Binding	DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process
Pathways			RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS		Brain cytoarchitecture ( 20308991)	Cognitive performance ( 20125193)
Protein-Protein Interactions		8 interactors: APP CBX5 CSNK1E DYNC1I1 ERBB2IP GTF2E2 NEK2 NFKBIB	23 interactors: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KLF5 MCC MDM2 MNAT1 NUP62 SND1 SUPT16H TBP XPA
Entrez ID		4163	2961
HPRD ID		01157	01800
Ensembl ID		ENSG00000171444	ENSG00000197265
Uniprot IDs		P23508	P29084
PDB IDs			1D8J 1D8K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Centriole-centriole Cohesion Basal Protein Localization Synaptic Growth At Neuromuscular Junction G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Centriole-centriole Cohesion Cell Growth Regulation Of Mitotic Centrosome Separation Collateral Sprouting Axon Midline Choice Point Recognition Microtubule-based Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase I Promoter Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping RNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Biosynthetic Process DNA Catabolic Process Regulation Of Metabolic Process MRNA Processing Negative Regulation Of Gene Expression
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Intersection) ?