MCC and ZNF12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCC	ZNF12
Description		MCC regulator of Wnt signaling pathway	zinc finger protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection	Nucleus Nucleoplasm Centrosome
	Molecular Function	Protein Binding Signaling Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Alzheimer's disease (APOE e4 interaction) ( 25778476) Body mass index ( 25673413) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	5 interacting genes: CARD10 MCC MDFI NDEL1 STX1A
Entrez ID		4163	7559
HPRD ID		01157	11835
Ensembl ID		ENSG00000171444	ENSG00000164631
Uniprot IDs		P23508	P17014
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome	Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Wnt Signaling Pathway Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Synaptic Vesicle Actomyosin Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion ATP-dependent Protein Binding Regulation Of Synaptic Vesicle Priming Response To Gravity SNARE Complex Assembly Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Chloride Channel Inhibitor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Protein Localization Myosin Head/neck Binding Calcium Channel Inhibitor Activity Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex CBM Complex Positive Regulation Of Catalytic Activity Activation Of NF-kappaB-inducing Kinase Activity Radial Glia-guided Pyramidal Neuron Migration Neurofilament Cytoskeleton Neurofilament Cytoskeleton Organization Centrosome Separation Positive Regulation Of Ruffle Assembly Mitotic Centrosome Separation Axon Hillock Inner Cell Mass Cell Proliferation
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