PPIE and KMT2A

Number of citations of the paper that reports this interaction (PubMedID 11313484)
40

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPIE	KMT2A
Description		peptidylprolyl isomerase E	lysine methyltransferase 2A
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Poly(A) Binding Cyclosporin A Binding Isomerase Activity	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication	Immune System Process Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Visual Learning Response To Light Stimulus Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Exploration Behavior Response To Potassium Ion Protein Modification Process Epigenetic Regulation Of Gene Expression T-helper 2 Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Short-term Neuronal Synaptic Plasticity Rhythmic Process Spleen Development Homeostasis Of Number Of Cells Within A Tissue Cognition Membrane Depolarization Definitive Hemopoiesis Protein-containing Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neutrophil degranulation mRNA Splicing - Major Pathway	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Blood protein levels ( 30072576)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: GTSE1 KMT2A PCM1 PHYHIP PRC1 PRPF6 SLU7 SUMO2 TRIM55 TRIM63 XAB2	33 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H2AC4 H2BC3 H3-3A H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A PSIP1 RBBP5 RBM39 RNF2 SBF1 SET SVIL TAF9 TASP1 WDR5
Entrez ID		10450	4297
HPRD ID		03893	01162
Ensembl ID		ENSG00000084072	ENSG00000118058
Uniprot IDs		E9PK21 Q9UNP9	A0AA34QVI8 E9PR05 Q03164
PDB IDs		1ZMF 2CQB 2KU7 2KYX 2R99 3LPY 3MDF 3UCH 5MQF 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 7A5P 7ABI 7W59 7W5A 7W5B 7ZEV 7ZEW 7ZEX 7ZEY 7ZEZ 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD	2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R 6W5I 6W5M 6W5N 7MBM 7MBN 7RZD 7RZJ 7S79 7S7D 7S8A 7S8E 7S8F 7U5V 7W67 7W6A 7W6I 7W6J 7ZEY 7ZEZ
Enriched GO Terms of Interacting Partners?		Catalytic Step 2 Spliceosome Microtubule MRNA Splicing, Via Spliceosome Spliceosomal Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Microtubule Cytoskeleton Second Spliceosomal Transesterification Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Protein-containing Complex Localization To Centriolar Satellite Mitotic Spindle Elongation Generation Of Catalytic Spliceosome For First Transesterification Step Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Nucleoplasm	MLL1 Complex Chromatin Remodeling MLL1/2 Complex Chromatin Organization Histone Methyltransferase Complex Set1C/COMPASS Complex Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex NSL Complex Structural Constituent Of Chromatin Negative Regulation Of DNA-templated Transcription Nucleoplasm MLL3/4 Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Neurohypophyseal Hormone Activity DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Nucleosome Assembly Protein-DNA Complex Assembly PRC1 Complex Nucleosome Euchromatin RING-like Zinc Finger Domain Binding Nucleosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Maternal Aggressive Behavior Positive Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Acetyltransferase Activity Positive Regulation Of Metabolic Process Cell Development Regulation Of Cell Cycle
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