MFF and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MFF	FXYD6
Description		mitochondrial fission factor	FXYD domain containing ion transport regulator 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Synaptic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Synapse	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Mitochondrial Fission Protein Targeting To Mitochondrion Mitochondrion Organization Peroxisome Fission Positive Regulation Of Mitochondrial Fission	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998) Refractive astigmatism ( 30306274)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		107 interacting genes: ADIPOQ AGPAT4 AIG1 ANKRD46 APOD APOL2 AQP3 AQP6 ATP6V0B BET1 C14orf180 C1QL4 C3orf52 CD79A CDIPT CEND1 CLDN19 CMTM5 CNIH1 COL4A5 CTXN3 CXCL16 CYB5B CYBC1 DNM1L ERGIC3 FAM209A FAM210B FAM3C FATE1 FCER1G FDCSP FXYD6 GJB1 GKN1 GOSR2 GPR152 IGFBP5 JAGN1 LAT LHFPL5 LPAR3 MEOX2 MIP MMGT1 MOSPD3 MPZL1 MTNR1B NIPAL3 NRM NTS OPN1SW OPRM1 PLK3 PLLP PLN PLP1 RAET1L RETREG3 RHBDL1 SACM1L SEC11C SEC22A SEC22B SEC23A SERINC2 SHISAL1 SLC18A3 SLC35B1 SLC41A2 SLC7A1 SLC7A14 SLC7A8 SMIM1 STRIT1 STX7 STX8 TEX264 TFRC TM6SF1 TMEM128 TMEM140 TMEM14C TMEM201 TMEM218 TMEM229B TMEM237 TMEM254 TMEM42 TMEM60 TMEM86B TMEM88 TMEM97 TMX2 TRAF3 TRAF3IP3 TRAM1L1 TRARG1 TSPAN2 TSPAN33 TSPO2 UBC UNC50 UNC93B1 UPK1B VAMP4 ZFPL1	67 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35E1 SLC35E3 SLC35H1 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		56947	53826
HPRD ID		16653	09456
Ensembl ID		ENSG00000168958	ENSG00000137726
Uniprot IDs		A0A0A0MS29 A0A9H3ZVE5 A0A9L9PY92 H7C433 Q9GZY8	Q9H0Q3
PDB IDs			8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Golgi Membrane Mitochondrial Outer Membrane Endomembrane System Membrane Fusion Water Channel Activity Vesicle-mediated Transport Magnesium Ion Transmembrane Transporter Activity Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Magnesium Ion Transmembrane Transport Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Magnesium Ion Transport Organelle Fusion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Organization Nuclear Inner Membrane Vesicle Fusion Regulation Of Protein Transport Cellular Localization Regulation Of Cellular Localization Water Transport Golgi Apparatus Organelle Membrane Fusion ER To Golgi Transport Vesicle Membrane Protein Localization To Cell Periphery Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cone Photoreceptor Outer Segment Chloride Channel Inhibitor Activity Inorganic Cation Transmembrane Transporter Activity Vesicle Organization Myelin Sheath Amino Acid Transmembrane Transporter Activity Negative Regulation Of Protein Transport Renal Water Transport Myeloid Cell Differentiation Neutrophil Differentiation Cobalt Ion Transport	Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Antiporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Monoatomic Ion Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid
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