MFF and DNM1L

Number of citations of the paper that reports this interaction (PMID 23530241)
10

Data Source:
BioGRID (pull down)

		MFF	DNM1L
Gene Name		mitochondrial fission factor	dynamin 1-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Peroxisome Synaptic Vesicle Cell Junction Integral Component Of Mitochondrial Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Golgi Apparatus Cytosol Microtubule Coated Pit Membrane Cell Junction Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding Lipid Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Protein Homooligomerization Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Targeting To Membrane Regulation Of Peroxisome Organization	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Dynamin Polymerization Involved In Mitochondrial Fission Endocytosis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Mitochondrion Organization Peroxisome Fission Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Protein Secretion Protein Homotetramerization Membrane Fusion Necroptotic Process Mitochondrion Morphogenesis Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Peroxisome Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: DNM1L	15 interactors: FIS1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF2 MUL1 PARK2 RRM2 SCG3 SH3GL1 SIRT3 VIM ZBTB24
Entrez ID		56947	10059
HPRD ID		16653	04833
Ensembl ID		ENSG00000168958	ENSG00000087470
Uniprot IDs		Q9GZY8	B4DGC9 B4DYR6 G8JLD5 J3KPI2 O00429 Q59GN9
PDB IDs			4BEJ 4H1U 4H1V
Enriched GO Terms of Interacting Partners?		Dynamin Polymerization Involved In Mitochondrial Fission Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Fission Peroxisome Fission Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Morphogenesis Mitochondrial Fission Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Necroptotic Process Programmed Necrotic Cell Death Necrotic Cell Death Peroxisome Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Homotetramerization Apoptotic Mitochondrial Changes Protein Localization To Mitochondrion Execution Phase Of Apoptosis Regulation Of Mitochondrion Organization Protein Tetramerization Protein Polymerization Membrane Fusion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Secretion Positive Regulation Of Apoptotic Signaling Pathway Protein Homooligomerization Positive Regulation Of Secretion Regulation Of Protein Complex Assembly Positive Regulation Of Protein Transport Cellular Protein Complex Assembly Apoptotic Signaling Pathway Regulation Of Protein Secretion Mitochondrion Organization Positive Regulation Of Organelle Organization Protein Oligomerization	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Mitochondrial Fusion Regulation Of Intracellular Transport Regulation Of Mitochondrial Fusion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Apoptotic Process Protein Localization To Mitochondrion Mitochondrial Fragmentation Involved In Apoptotic Process Programmed Cell Death Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Transport Peroxisome Fission Positive Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Signal Transduction Mitochondrial Fusion Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Mitochondrion Morphogenesis Regulation Of JNK Cascade Mitochondrion Degradation Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Mitochondrion Organization Protein Localization To Organelle Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Organelle Disassembly Activation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Peroxisome Organization
Tagcloud ?		allotted angus beef bw carcass dissected gain gains heifers hereford inseparable intermuscular kph lean lf nefa om partitioning puberty seam slaughter slaughtered slower sole udder viscera wk yr	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Difference) ?		allotted angus beef bw carcass dissected gain gains heifers hereford inseparable intermuscular kph lean lf nefa om partitioning puberty seam slaughter slaughtered slower sole udder viscera wk yr	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Intersection) ?