MRPS22 and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		MRPS22	SUMO4
Description		mitochondrial ribosomal protein S22	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Nucleus SUMO Ligase Complex
	Molecular Function	Structural Constituent Of Ribosome Protein Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Mitochondrial Translation	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Ear morphology ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Male-pattern baldness ( 27182965) Obesity-related traits ( 22013104 23251661) Offspring birth weight ( 31043758) Rosacea symptom severity ( 29771307)	Dupuytren's disease ( 28886342)
Interacting Genes		7 interacting genes: BARD1 BTK ERCC6 PTEN SHD SUMO4 UBC	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		56945	387082
HPRD ID		10430	10584
Ensembl ID		ENSG00000175110	ENSG00000177688
Uniprot IDs		A0A7P0MKV3 P82650	Q6EEV6
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Tag Activity Negative Regulation Of Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cell Cycle Process Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of MRNA 3'-end Processing Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Response To Oxidative Stress Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphorylation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Cell Cycle Phase Transition BRCA1-BARD1 Complex Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission BRCA1-B Complex Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stress Histamine Secretion By Mast Cell Response To Reactive Oxygen Species Response To Molecule Of Fungal Origin Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Protein Metabolic Process	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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