MRPS22 and SHD

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MRPS22	SHD
Description		mitochondrial ribosomal protein S22	Src homology 2 domain containing transforming protein D
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Structural Constituent Of Ribosome Protein Binding	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	Mitochondrial Translation
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Ear morphology ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Male-pattern baldness ( 27182965) Obesity-related traits ( 22013104 23251661) Offspring birth weight ( 31043758) Rosacea symptom severity ( 29771307)	Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		7 interacting genes: BARD1 BTK ERCC6 PTEN SHD SUMO4 UBC	14 interacting genes: ABL1 BECN1 CAPN10 EGFR ERBB2 ERBB3 ERBB4 KRTCAP2 MET MRPS22 NCK2 OLIG1 OSBPL6 PSG11
Entrez ID		56945	56961
HPRD ID		10430	15337
Ensembl ID		ENSG00000175110	ENSG00000105251
Uniprot IDs		A0A7P0MKV3 P82650	Q96IW2
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Tag Activity Negative Regulation Of Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cell Cycle Process Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of MRNA 3'-end Processing Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Response To Oxidative Stress Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphorylation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Cell Cycle Phase Transition BRCA1-BARD1 Complex Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission BRCA1-B Complex Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stress Histamine Secretion By Mast Cell Response To Reactive Oxygen Species Response To Molecule Of Fungal Origin Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Protein Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Receptor Complex ERBB3:ERBB2 Complex Protein Kinase Activity Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Apoptotic Process Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB2-EGFR Signaling Pathway Glial Cell Development Positive Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of Apoptotic Process Basolateral Plasma Membrane Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Animal Organ Development Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Endosome Membrane Protein Tyrosine Kinase Activator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glial Cell Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Signal Transduction
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