ARNTL2 and EPAS1

Number of citations of the paper that reports this interaction (PMID 11018023)
21

Data Source:
HPRD (in vitro, two hybrid)

		ARNTL2	EPAS1
Gene Name		aryl hydrocarbon receptor nuclear translocator-like 2	endothelial PAS domain protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Nucleolus Cytoplasm	Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Dimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Positive Regulation Of Circadian Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Transcription From RNA Polymerase II Promoter Mitochondrion Organization Signal Transduction Visual Perception Erythrocyte Differentiation Lung Development Somatic Stem Cell Maintenance Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS			Renal cell carcinoma ( 21131975)
Protein-Protein Interactions		4 interactors: CLOCK EPAS1 NPAS2 UBC	32 interactors: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 EWSR1 F12 HSP90AA1 JUN KLHL20 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL
Entrez ID		56938	2034
HPRD ID		16507	06787
Ensembl ID			ENSG00000116016
Uniprot IDs		Q8WYA1	B3KW07 Q99814
PDB IDs		2KDK	1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Response To Redox State Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Rhythmic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Transcription, DNA-templated Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Biosynthetic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Damage Checkpoint RNA Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Gene Expression Cellular Macromolecule Biosynthetic Process Cell Cycle Checkpoint Macromolecule Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hypoxia Myoblast Fate Commitment Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Circadian Sleep/wake Cycle Nucleobase-containing Compound Metabolic Process Locomotor Rhythm Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Viral Protein Processing Surfactant Homeostasis	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Response To Stimulus Anatomical Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process System Development Developmental Process Nitrogen Compound Metabolic Process RNA Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Cellular Response To Oxygen Levels Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Leukocyte Activation Biosynthetic Process Leukocyte Differentiation Response To External Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Myeloid Leukocyte Differentiation
Tagcloud ?		aiming circadian clinicopathological clock clockwork coefficients compromised coordinated cry2 disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker	2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Difference) ?		aiming circadian clinicopathological clock clockwork coefficients compromised coordinated cry2 disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker	2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Intersection) ?