BMAL2 and CLOCK

Number of citations of the paper that reports this interaction (PubMedID 10864977)
0

Data Source:
HPRD (in vitro, in vivo)

		BMAL2	CLOCK
Description		basic helix-loop-helix ARNT like 2	clock circadian regulator
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Chromatoid Body CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Entrainment Of Circadian Clock Circadian Regulation Of Gene Expression Positive Regulation Of Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	DNA Damage Checkpoint Signaling Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation DNA Damage Response Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression	BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression HATs acetylate histones Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Drugs
Diseases
GWAS			A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: CLOCK CTTNBP2 EPAS1 MEOX2 RORC	26 interacting genes: ARNT BHLHE41 BMAL1 BMAL2 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1
Entrez ID		56938	9575
HPRD ID		16507	03508
Ensembl ID		ENSG00000029153	ENSG00000134852
Uniprot IDs		Q8WYA1	O15516 Q3ZCT4 Q53EU0
PDB IDs		2KDK	4H10 6QPJ
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Circadian Rhythm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Circadian Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Regulation Of Circadian Rhythm Positive Regulation Of RNA Metabolic Process Circadian Rhythm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Myoblast Fate Commitment Ligand-modulated Transcription Factor Activity DNA Binding Protein Dimerization Activity T-helper 17 Cell Differentiation Somite Specification CLOCK-BMAL Transcription Complex Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Peyer's Patch Development Rhythmic Process Mucosa-associated Lymphoid Tissue Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Biosynthetic Process Negative Regulation Of Thymocyte Apoptotic Process Intracellular Oxygen Homeostasis Postsynaptic Actin Cytoskeleton Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Thymocyte Apoptotic Process Chromatoid Body Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Norepinephrine Metabolic Process Segment Specification Somite Development Oxysterol Binding Response To Redox State Regulation Of Modification Of Postsynaptic Structure FAR/SIN/STRIPAK Complex Surfactant Homeostasis	Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Photoperiodism Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Chromatin Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nuclear Receptor Activity Gluconeogenesis Hexose Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Carbohydrate Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Negative Regulation Of Circadian Rhythm Carbohydrate Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Metabolic Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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