ARNTL2 and CLOCK

Number of citations of the paper that reports this interaction (PMID 11018023)
21

Data Source:
HPRD (in vitro, in vivo)

		ARNTL2	CLOCK
Gene Name		aryl hydrocarbon receptor nuclear translocator-like 2	clock circadian regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Nucleolus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Dimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Positive Regulation Of Circadian Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Damage Checkpoint Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	PPARA activates gene expression Chromatin modifying enzymes Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression HATs acetylate histones BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Personality dimensions ( 18957941)
Protein-Protein Interactions		4 interactors: CLOCK EPAS1 NPAS2 UBC	7 interactors: ARNTL ARNTL2 EP300 KAT2B PER3 RARA RXRA
Entrez ID		56938	9575
HPRD ID		16507	03508
Ensembl ID			ENSG00000134852
Uniprot IDs		Q8WYA1	O15516 Q3ZCT4 Q53EU0
PDB IDs		2KDK	4H10
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Response To Redox State Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Rhythmic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Transcription, DNA-templated Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Biosynthetic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Damage Checkpoint RNA Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Gene Expression Cellular Macromolecule Biosynthetic Process Cell Cycle Checkpoint Macromolecule Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hypoxia Myoblast Fate Commitment Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Circadian Sleep/wake Cycle Nucleobase-containing Compound Metabolic Process Locomotor Rhythm Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Viral Protein Processing Surfactant Homeostasis	Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Transcription, DNA-templated RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Circadian Rhythm Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway N-terminal Protein Amino Acid Modification Signal Transduction Ventricular Cardiac Muscle Cell Differentiation DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Cell Communication Positive Regulation Of Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		aiming circadian clinicopathological clock clockwork coefficients compromised coordinated cry2 disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker	albuginea bothersome bump bumps corporal corpus correcting curvature disadvantages dorsum entails erection impotence intercourse neurovascular nonabsorbable palpable penis phenylephrine plication plications priapism recurred requested spongiosum straighter straightness sutures thickest tunica
Tagcloud (Difference) ?		aiming circadian clinicopathological clock clockwork coefficients compromised coordinated cry2 disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker	albuginea bothersome bump bumps corporal corpus correcting curvature disadvantages dorsum entails erection impotence intercourse neurovascular nonabsorbable palpable penis phenylephrine plication plications priapism recurred requested spongiosum straighter straightness sutures thickest tunica
Tagcloud (Intersection) ?