BMAL2 and CTTNBP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BMAL2	CTTNBP2
Name		basic helix-loop-helix ARNT like 2	cortactin binding protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex	Cytoplasm Cell Cortex Synaptic Vesicle Cell Projection Dendritic Spine Synapse FAR/SIN/STRIPAK Complex Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding	Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Entrainment Of Circadian Clock Circadian Regulation Of Gene Expression Positive Regulation Of Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Regulation Of Synapse Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) General factor of neuroticism ( 30867560 ) Glaucoma ( 30054594 31959993 ) Glaucoma (primary open-angle) ( 33627673 29891935 ) Idiopathic osteonecrosis of the femoral head ( 28000841 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Myocardial infarction ( 33532862 ) Positive urgency ( 30718321 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Smoking initiation ( 30617275 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (current vs never) ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Sociability score ( 34054130 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 30108155 ) Type 2 diabetes ( 30297969 30054458 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Worry too long after an embarrassing experience ( 34054130 )
Novel Interactors		None recorded	1 novel interactors: IMMP2L
Interacting Genes		5 interacting genes: CLOCK CTTNBP2 EPAS1 MEOX2 RORC	10 interacting genes: APPL1 BMAL2 CTTN FAM86C1P HSF2BP INCA1 KRT14 MAGEA11 MEI4 PKNOX2
Entrez ID		56938	83992
HPRD ID		16507	09890
Ensembl ID		ENSG00000029153	ENSG00000077063
Uniprot IDs		Q8WYA1	Q20BG9 Q8WZ74
PDB IDs		2KDK	Not available
GO Terms Enriched among Interactors		Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Circadian Rhythm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Circadian Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Regulation Of Circadian Rhythm Positive Regulation Of RNA Metabolic Process Circadian Rhythm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Myoblast Fate Commitment Ligand-modulated Transcription Factor Activity DNA Binding Protein Dimerization Activity T-helper 17 Cell Differentiation Somite Specification CLOCK-BMAL Transcription Complex Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Peyer's Patch Development Rhythmic Process Mucosa-associated Lymphoid Tissue Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Biosynthetic Process Negative Regulation Of Thymocyte Apoptotic Process Intracellular Oxygen Homeostasis Postsynaptic Actin Cytoskeleton Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Thymocyte Apoptotic Process Chromatoid Body Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Norepinephrine Metabolic Process Segment Specification Somite Development Oxysterol Binding Response To Redox State Regulation Of Modification Of Postsynaptic Structure FAR/SIN/STRIPAK Complex Surfactant Homeostasis	None