SMARCAD1 and TOPBP1

Number of citations of the paper that reports this interaction (PubMedID 28063255)
62

Data Source:
BioGRID (two hybrid, pull down)

		SMARCAD1	TOPBP1
Description		SNF2 related chromatin remodeling ATPase with DExD box 1	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Nuclear Replication Fork	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Site Of Double-strand Break BRCA1-B Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	DNA Binding Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding Chromatin-protein Adaptor Activity
	Biological Process	Regulation Of DNA Recombination DNA Double-strand Break Processing DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Chromosome Separation	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication Initiation DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling Homologous Recombination Chromosome Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Via Alternative Nonhomologous End Joining Broken Chromosome Clustering Protein Localization To Site Of Double-strand Break
Pathways			HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604732 28604728 23666239) Type 2 diabetes ( 30297969)	Iron status biomarkers ( 19084217)
Interacting Genes		7 interacting genes: CBS GTF3C3 PCNA SUMO1 SUMO2 TOPBP1 TRIM28	30 interacting genes: ABL1 AKT1 ATM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 GINS1 HUS1 NFYA PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 SMARCAD1 TBC1D4 TCFL5 TEX11 TOP2B UBR5 USP13 ZBTB17
Entrez ID		56916	11073
HPRD ID		11586	09678
Ensembl ID		ENSG00000163104	ENSG00000163781
Uniprot IDs		Q9H4L7	A0A2R8YD63 A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		6H3A 6QU1 7Z36	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 7CMZ 8OK2
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Protein Sumoylation DNA Metabolic Process Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process PML Body Protein Tag Activity Macromolecule Metabolic Process SUMO Transferase Activity DNA Repair Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Response To Cadmium Ion DNA Damage Response Male Germ Cell Nucleus Cellular Response To Stress PCNA Complex Replisome Regulation Of Protein Import Into Nucleus Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Nuclear Body Enzyme Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Broken Chromosome Clustering Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Localization To Nuclear Pore Ubiquitin-like Protein Ligase Activity Cellular Detoxification Of Cadmium Ion Cysteine Biosynthetic Process L-serine Catabolic Process Transsulfuration Homocysteine Catabolic Process	DNA Metabolic Process Negative Regulation Of Cell Cycle DNA Damage Response Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleoplasm DNA Repair Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome Macromolecule Metabolic Process Checkpoint Clamp Complex Negative Regulation Of Mitotic Cell Cycle DNA Double-strand Break Processing Intracellular Signal Transduction Nucleus Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Process Homologous Recombination Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Response To Stress DNA Recombination Cellular Senescence DNA Replication Checkpoint Signaling Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of DNA Metabolic Process
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