SMARCAD1 and GTF3C3

Number of citations of the paper that reports this interaction (PubMedID 37761933)
99

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SMARCAD1	GTF3C3
Description		SNF2 related chromatin remodeling ATPase with DExD box 1	general transcription factor IIIC subunit 3
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Nuclear Replication Fork	Transcription Factor TFIIIC Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Regulation Of DNA Recombination DNA Double-strand Break Processing DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Chromosome Separation	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways			RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604732 28604728 23666239) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: CBS GTF3C3 PCNA SUMO1 SUMO2 TOPBP1 TRIM28	11 interacting genes: BRF1 DEDD DEDD2 GTF3C5 HNRNPD NEDD8 PCBD1 PTEN SMARCAD1 TBP UBC
Entrez ID		56916	9330
HPRD ID		11586	11997
Ensembl ID		ENSG00000163104	ENSG00000119041
Uniprot IDs		Q9H4L7	Q9Y5Q9
PDB IDs		6H3A 6QU1 7Z36	8CLK
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Protein Sumoylation DNA Metabolic Process Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process PML Body Protein Tag Activity Macromolecule Metabolic Process SUMO Transferase Activity DNA Repair Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Response To Cadmium Ion DNA Damage Response Male Germ Cell Nucleus Cellular Response To Stress PCNA Complex Replisome Regulation Of Protein Import Into Nucleus Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Nuclear Body Enzyme Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Broken Chromosome Clustering Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Localization To Nuclear Pore Ubiquitin-like Protein Ligase Activity Cellular Detoxification Of Cadmium Ion Cysteine Biosynthetic Process L-serine Catabolic Process Transsulfuration Homocysteine Catabolic Process	RNA Polymerase III General Transcription Initiation Factor Activity Nucleoplasm Transcription By RNA Polymerase III Nucleus Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Initiation TRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Tag Activity Regulation Of RNA Metabolic Process Macromolecule Metabolic Process RRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Response To Electrical Stimulus Regulation Of Transcription By RNA Polymerase I Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Synaptic Vesicle Clustering U11/U12 SnRNP Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Circadian Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Binding Transcription Factor TFIIIB Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process
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