SMARCAD1

Description		SNF2 related chromatin remodeling ATPase with DExD box 1
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity
	Biological Process	Regulation Of DNA Recombination DNA Double-strand Break Processing DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Chromosome Separation
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604732 28604728 23666239) Type 2 diabetes ( 30297969)
Novel Interacting Genes		1 novel interacting genes: SLC39A8
Interacting Genes		7 interacting genes: CBS GTF3C3 PCNA SUMO1 SUMO2 TOPBP1 TRIM28
Entrez ID		56916
HPRD ID		11586
Ensembl ID		ENSG00000163104
Uniprot IDs		Q9H4L7
PDB IDs		6H3A 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Protein Sumoylation DNA Metabolic Process Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process PML Body Protein Tag Activity Macromolecule Metabolic Process SUMO Transferase Activity DNA Repair Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Response To Cadmium Ion DNA Damage Response Male Germ Cell Nucleus Cellular Response To Stress PCNA Complex Replisome Regulation Of Protein Import Into Nucleus Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Nuclear Body Enzyme Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Broken Chromosome Clustering Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Localization To Nuclear Pore Ubiquitin-like Protein Ligase Activity Cellular Detoxification Of Cadmium Ion Cysteine Biosynthetic Process L-serine Catabolic Process Transsulfuration Homocysteine Catabolic Process
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