C1GALT1 and GSDME

Data Source: HiPPIP (Novel)

		C1GALT1	GSDME
Name		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	gasdermin E
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding
	Biological Process	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins	Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Diseases		None	Deafness, autosomal dominant
GWAS		Aspartate aminotransferase levels ( 33547301 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Coronary artery disease ( 29212778 ) Daytime sleep phenotypes ( 27126917 ) Diastolic blood pressure ( 30224653 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) FEV1 ( 30804560 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Multiple sclerosis (severity) ( 19010793 ) Night sleep phenotypes ( 27126917 ) Peak expiratory flow ( 30804560 ) Refractive error ( 32231278 ) Serum galactose-deficient IgA1 levels ( 28187132 ) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824 ) Smooth-surface caries ( 24556642 ) Systolic blood pressure ( 26969751 ) Visceral adipose tissue adjusted for BMI ( 22589738 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: GSDME TRAF6	8 novel interactors: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 TBX19 VPS41
Interacting Genes		35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1	5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1
Entrez ID		56913	1687
HPRD ID		16631	02996
Ensembl ID		ENSG00000106392	ENSG00000105928
Uniprot IDs		A0A024RA32 Q9NS00	A4FVA8 O60443
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane	Cellular Response To Forskolin Response To Forskolin