GSDME and GARS1

		GSDME	GARS1
Description		gasdermin E	glycyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Secretory Granule Axon Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	Nucleotide Binding Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Aminoacyl-tRNA Ligase Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Hydrolase Activity Ligase Activity Identical Protein Binding Protein Dimerization Activity ATP:ATP Adenylyltransferase Activity
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Translation TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis	Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs			Glycine
Diseases		Deafness, autosomal dominant	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS
Interacting Genes		5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1	12 interacting genes: CD44 CEBPA CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8
Entrez ID		1687	2617
HPRD ID		02996	02617
Ensembl ID		ENSG00000105928	ENSG00000106105
Uniprot IDs		A4FVA8 O60443	P41250
PDB IDs			2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin	Peptidyl-threonine Phosphorylation Protein Neddylation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Peptidyl-serine Phosphorylation Regulation Of Postsynapse Assembly
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