GSDME and GPNMB

		GSDME	GPNMB
Description		gasdermin E	glycoprotein nmb
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Melanosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis	PTK6 promotes HIF1A stabilization
Drugs			Glembatumumab vedotin
Diseases		Deafness, autosomal dominant
GWAS			Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1	4 interacting genes: EGFR ITSN2 LINC01139 SMAD4
Entrez ID		1687	10457
HPRD ID		02996	05081
Ensembl ID		ENSG00000105928	ENSG00000136235
Uniprot IDs		A4FVA8 O60443	Q14956 Q96F58
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin	Negative Regulation Of Cardiocyte Differentiation Intracellular Vesicle Regulation Of Cell Growth Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of MAPK Cascade Regulation Of Growth Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epidermal Growth Factor Binding Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Protein Kinase C Signaling Sulfate Binding Endocardial Cell Differentiation Wide Pore Channel Activity Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway MAPK Cascade SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Tube Morphogenesis Regulation Of ERK1 And ERK2 Cascade
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