GSDME and VPS41

Data Source: HiPPIP (Novel)

		GSDME	VPS41
Name		gasdermin E	VPS41 subunit of HOPS complex
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Cytosol Endosome Membrane Microtubule Cytoskeleton Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Clathrin Complex Lysosomal HOPS Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	Protein Binding Microtubule Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Targeting To Vacuole Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Protein Transport Vesicle-mediated Transport Macroautophagy Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Golgi Vesicle Transport Late Endosome To Lysosome Transport
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis	SARS-CoV-2 modulates autophagy
Diseases		Deafness, autosomal dominant	None
GWAS		No GWAS studies recorded	Breast cancer and/or colorectal cancer ( 29698419 ) Cognitive performance ( 19734545 )
Novel Interactors		8 novel interactors: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 TBX19 VPS41	2 novel interactors: ARID1A GSDME
Interacting Genes		5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1	12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B
Entrez ID		1687	27072
HPRD ID		02996	10402
Ensembl ID		ENSG00000105928	ENSG00000006715
Uniprot IDs		A4FVA8 O60443	P49754
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cellular Response To Forskolin Response To Forskolin	Endosome To Lysosome Transport Vacuolar Transport Early Endosome To Late Endosome Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Vesicle Organization HOPS Complex Endosomal Transport Vesicle-mediated Transport Intracellular Transport Endosome Organization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Lysosome Organization Vacuole Organization Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Protein Localization Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Presynaptic Endosome Cytoplasmic Microtubule Organization Microtubule-based Process Axo-dendritic Transport Protein Localization To Vacuole Phagosome-lysosome Fusion Neurotransmitter Receptor Transport Synaptic Vesicle Recycling Protein Localization To Organelle Ubiquitin-like Protein Transferase Activity Lysosomal Membrane Viral Process Negative Regulation Of MiRNA Transcription Viral Release From Host Cell Late Endosome Membrane Organelle Organization Ubiquitin Conjugating Enzyme Activity Transport Along Microtubule Vesicle Budding From Membrane Organelle Localization Lysosome Supramolecular Fiber Organization Protein Targeting Anterograde Axonal Transport Positive Regulation Of Protein Catabolic Process Microtubule-based Transport