GSDME and C1GALT1

		GSDME	C1GALT1
Description		gasdermin E	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Golgi Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis	Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins
Drugs
Diseases		Deafness, autosomal dominant
GWAS			Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1	35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1
Entrez ID		1687	56913
HPRD ID		02996	16631
Ensembl ID		ENSG00000105928	ENSG00000106392
Uniprot IDs		A4FVA8 O60443	A0A024RA32 Q9NS00
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin	Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane
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