GSDME and TBX19

		GSDME	TBX19
Description		gasdermin E	T-box transcription factor 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Chromatin Nucleus
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mesoderm Formation Cell Fate Specification Heart Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Pituitary Gland Development Regulation Of Cell Population Proliferation Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases		Deafness, autosomal dominant	Adrenocorticotropic hormone deficiency; Isolated ACDH deficiency (IAD)
GWAS
Interacting Genes		5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1	15 interacting genes: GCM2 HGS HOXC8 IRX6 LONRF1 NEDD9 NR5A1 PITX1 POGZ PRR35 RAB2B TBX6 TFG VENTX ZIC1
Entrez ID		1687	9095
HPRD ID		02996	05214
Ensembl ID		ENSG00000105928	ENSG00000143178
Uniprot IDs		A4FVA8 O60443	B3KRD9 O60806
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin	Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation DNA-binding Transcription Factor Activity Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Immunological Synapse Formation Regulation Of Primary Metabolic Process Negative Regulation Of Female Gonad Development Primary Sex Determination Regulation Of RNA Metabolic Process Gland Development Regulation Of Metabolic Process Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Negative Regulation Of Neuron Maturation ESCRT-0 Complex Positive Regulation Of Exocytosis
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