C1GALT1 and SLC14A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1GALT1	SLC14A1
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	solute carrier family 14 member 1 (Kidd blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Water Transmembrane Transporter Activity Protein Binding Urea Transmembrane Transporter Activity Urea Channel Activity
	Biological Process	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development	Water Transport Urea Transport Establishment Of Localization In Cell Transmembrane Transport Urea Transmembrane Transport
Pathways		Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins	SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)	Bladder cancer ( 21750109 21824976) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Pursuit maintenance gain ( 29064472) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1	12 interacting genes: BTN2A2 C1GALT1 CFTR FIS1 GIMAP1 MIP RTP2 SNORC STRIT1 THSD7B TMEM97 TMIE
Entrez ID		56913	6563
HPRD ID		16631	00195
Ensembl ID		ENSG00000106392	ENSG00000141469
Uniprot IDs		A0A024RA32 Q9NS00	B4DFJ8 B4DHU3 F5GWS2 G0W2N5 Q13336
PDB IDs			6QD5 8BLP 8XDF
Enriched GO Terms of Interacting Partners?		Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane	Membrane Water Transport
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