C1GALT1 and SLC1A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1GALT1	SLC1A1
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	solute carrier family 1 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Vesicle Asymmetric Synapse Neuron Projection Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Synapse Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Schaffer Collateral - CA1 Synapse Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Monoatomic Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development	Behavioral Fear Response Response To Amphetamine Regulation Of Heart Rate Glutathione Metabolic Process Glutathione Biosynthetic Process Superoxide Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Grooming Behavior Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Cellular Response To Oxidative Stress Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization Neuron Apoptotic Process L-glutamate Import Righting Reflex Retina Development In Camera-type Eye Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transmembrane Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Intracellular Glutamate Homeostasis Motor Neuron Apoptotic Process Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Cellular Response To Bisphenol A Conditioned Place Preference
Pathways		Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins	Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids
Drugs			Aspartic acid Glutamic acid
Diseases			Dicarboxylic aminoaciduria
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		56913	6505
HPRD ID		16631	00597
Ensembl ID		ENSG00000106392	ENSG00000106688
Uniprot IDs		A0A024RA32 Q9NS00	P43005
PDB IDs			6S3Q 6X2L 6X2Z 6X3E 6X3F 7NSG 8CTC 8CTD 8CUA 8CUD 8CUI 8CUJ 8CV2 8CV3 9D66 9D67 9D68 9D69 9D6A
Enriched GO Terms of Interacting Partners?		Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane
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