C1GALT1 and C1GALT1C1

Number of citations of the paper that reports this interaction (PubMedID 18695044)
34

Data Source:
BioGRID (pull down)

		C1GALT1	C1GALT1C1
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	C1GALT1 specific chaperone 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane	Golgi Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity
	Biological Process	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development	Protein O-linked Glycosylation Platelet Activation Platelet Morphogenesis
Pathways		Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins	Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)	Serum galactose-deficient IgA1 levels ( 28187132)
Interacting Genes		35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1	3 interacting genes: B3GNT2 C1GALT1 LGALS3
Entrez ID		56913	29071
HPRD ID		16631	06462
Ensembl ID		ENSG00000106392	ENSG00000171155
Uniprot IDs		A0A024RA32 Q9NS00	Q96EU7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane	Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Glycosylation Macromolecule Glycosylation Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Glycoprotein Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Glycoprotein Metabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Poly-N-acetyllactosamine Metabolic Process Signaling Receptor Inhibitor Activity NK T Cell Activation N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Intestinal Epithelial Cell Development Carbohydrate Derivative Biosynthetic Process Oligosaccharide Binding Keratan Sulfate Proteoglycan Biosynthetic Process Regulation Of Dendritic Cell Differentiation Keratan Sulfate Proteoglycan Metabolic Process Columnar/cuboidal Epithelial Cell Development Macrophage Chemotaxis Laminin Binding Macrophage Migration Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Golgi Membrane Hexosyltransferase Activity Positive Regulation Of Calcium Ion Import Negative Regulation Of T Cell Receptor Signaling Pathway Chemoattractant Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Carbohydrate Derivative Metabolic Process Regulation Of T Cell Apoptotic Process Immunological Synapse Positive Chemotaxis Regulation Of Calcium Ion Import Protein Phosphatase Inhibitor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Molecular Condensate Scaffold Activity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Receptor Signaling Pathway
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