TMEM167B and MGST2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM167B	MGST2
Name		transmembrane protein 167B	microsomal glutathione S-transferase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Oxidoreductase Activity Transferase Activity Lyase Activity Identical Protein Binding Glutathione Binding
	Biological Process	Constitutive Secretory Pathway	Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process Response To Lipopolysaccharide Carboxylic Acid Biosynthetic Process Membrane Lipid Catabolic Process Positive Regulation Of Inflammatory Response Cellular Oxidant Detoxification
Pathways		None	Glutathione conjugation Aflatoxin activation and detoxification
Drugs		None	Glutathione
GWAS		Apolipoprotein B levels ( 32203549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Serum alkaline phosphatase levels ( 33547301 )	Metabolite levels ( 23823483 )
Interacting Genes		33 interacting genes: ACKR2 AGPAT3 APOL3 AQP10 AQP6 ASPH C14orf180 CD300C CD47 CTXN3 EBP FXYD6-FXYD2 HSD17B11 HSD17B13 LETMD1 LSS MGST2 PLLP REEP4 SACM1L SEC22B SERINC2 SLC34A3 SLC71A2 SMPD2 STX12 STX1B TAS2R19 TM4SF19 TMEM100 TMEM107 UNC50 ZDHHC21	23 interacting genes: ASIC1 BCL2L10 BCL2L2 C3orf52 CCL3L3 CLEC14A CREB3 CREB3L1 CTXN3 DNAJC30 GIMAP5 GJA8 GPX8 HDHD2 PLN PNKP SEC22A SEC22B SGCB STX8 TMEM167B TMEM207 VAMP3
Entrez ID		56900	4258
HPRD ID		16474	03436
Ensembl ID		ENSG00000215717	ENSG00000085871
Uniprot IDs		A0A494C0V7 Q9NRX6	Q99735
PDB IDs		Not available	6SSR 6SSS 6SSU 6SSW
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Steroid Dehydrogenase Activity Lipid Droplet SNAP Receptor Activity Lipid Metabolic Process Water Channel Activity Lipid Biosynthetic Process Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity	SNAP Receptor Activity Membrane Membrane Fusion