EIF4E and EIF4EBP2

Number of citations of the paper that reports this interaction (PMID 7935836)
262

Data Source:
HPRD (in vitro, in vivo)

		EIF4E	EIF4EBP2
Gene Name		eukaryotic translation initiation factor 4E	eukaryotic translation initiation factor 4E binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Extracellular Vesicular Exosome
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Eukaryotic Initiation Factor 4G Binding Poly(A) RNA Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Lung Development Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle	Translation Insulin Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Translational Initiation
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling Transport of the SLBP independent Mature mRNA mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation Release of eIF4E Transport of Mature Transcript to Cytoplasm Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Insulin receptor signalling cascade Deadenylation of mRNA Translation Transport of Mature mRNA derived from an Intron-Containing Transcript ISG15 antiviral mechanism Transport of Mature mRNAs Derived from Intronless Transcripts Interferon Signaling Cytokine Signaling in Immune system IRS-related events Release of eIF4E L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs		7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate 7-Methyl-Guanosine-5\'-Triphosphate 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APP CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG RPS6KA5 TDO2 TRIM27 UBXN11	2 interactors: EIF4E MTOR
Entrez ID		1977	1979
HPRD ID		00591	03747
Ensembl ID			ENSG00000148730
Uniprot IDs		P06730 Q32Q75	Q13542
PDB IDs		1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4DT6 4DUM	3AM7
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Signal Transduction Protein Phosphorylation Signaling Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Histone H3-T6 Phosphorylation Gene Expression Negative Regulation Of Translation Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Translational Initiation Cellular Response To Stimulus Cell Death Death Phosphorylation Intracellular Signal Transduction Histone Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Growth Factor Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Apoptotic Process Platelet Activation Translation Programmed Cell Death Regulation Of Mitotic Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Cytokine Neurotrophin Signaling Pathway MRNA 3'-end Processing Cytokine-mediated Signaling Pathway	Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Utilization Cellular Response To Insulin Stimulus Regulation Of Translation Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Response To Peptide Negative Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase III Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Macroautophagy Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Size Response To Organonitrogen Compound Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Lamellipodium Organization Regulation Of Response To Food Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Regulation Of Rac GTPase Activity TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Lamellipodium Assembly Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Cellular Response To Heat Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Myotube Differentiation Negative Regulation Of Autophagy Regulation Of Rac Protein Signal Transduction Ruffle Organization Regulation Of Glycogen Metabolic Process Positive Regulation Of Stress Fiber Assembly Peptidyl-threonine Phosphorylation Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of Myelination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Lipid Catabolic Process Regulation Of Myotube Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Stress Fiber Assembly Cellular Response To Heat
Tagcloud ?		4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation	aa ampk biopsies bovine competition dataset elf5 emerging existence favoring frap1 gland glucose gsk3a harvested inferred lactation mammary mapk14 milk mtor pregnancy ribosomal rpl22 stat5 transcripts translational transporters tsc1
Tagcloud (Difference) ?		4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial skeletal soleus synthesis translation	aa ampk biopsies bovine competition dataset elf5 emerging existence favoring frap1 gland glucose gsk3a harvested inferred lactation mammary mapk14 milk mtor pregnancy rpl22 stat5 transcripts translational transporters tsc1
Tagcloud (Intersection) ?		ribosomal