EIF4E and EIF4EBP3

Number of citations of the paper that reports this interaction (PMID 9593750)
51

Data Source:
HPRD (in vitro, in vivo)

		EIF4E	EIF4EBP3
Gene Name		eukaryotic translation initiation factor 4E	eukaryotic translation initiation factor 4E binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Extracellular Vesicular Exosome	Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Eukaryotic Initiation Factor 4G Binding Poly(A) RNA Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Lung Development Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle	Negative Regulation Of Translational Initiation
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling Transport of the SLBP independent Mature mRNA mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation Release of eIF4E Transport of Mature Transcript to Cytoplasm Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Insulin receptor signalling cascade Deadenylation of mRNA Translation Transport of Mature mRNA derived from an Intron-Containing Transcript ISG15 antiviral mechanism Transport of Mature mRNAs Derived from Intronless Transcripts Interferon Signaling Cytokine Signaling in Immune system IRS-related events Release of eIF4E L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs		7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate 7-Methyl-Guanosine-5\'-Triphosphate 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APP CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG RPS6KA5 TDO2 TRIM27 UBXN11	2 interactors: EIF4E EIF4E2
Entrez ID		1977	8637
HPRD ID		00591	09149
Ensembl ID			ENSG00000243056
Uniprot IDs		P06730 Q32Q75	O60516
PDB IDs		1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4DT6 4DUM
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Signal Transduction Protein Phosphorylation Signaling Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Histone H3-T6 Phosphorylation Gene Expression Negative Regulation Of Translation Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Translational Initiation Cellular Response To Stimulus Cell Death Death Phosphorylation Intracellular Signal Transduction Histone Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Growth Factor Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Apoptotic Process Platelet Activation Translation Programmed Cell Death Regulation Of Mitotic Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Cytokine Neurotrophin Signaling Pathway MRNA 3'-end Processing Cytokine-mediated Signaling Pathway	Translational Initiation Regulation Of Translation Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Cytokine Stimulus Translation Response To Cytokine Nuclear-transcribed MRNA Poly(A) Tail Shortening
Tagcloud ?		4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation	4f 5q31 alex ankyrin arises bps eif4g exons exploitation frame genbank introns kh kua mask originating photoreceptor reading repressors searches sequestering tags uev1 uncovered underscores xlalphas
Tagcloud (Difference) ?		4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation	4f 5q31 alex ankyrin arises bps exons exploitation frame genbank introns kh kua mask originating photoreceptor reading repressors searches sequestering tags uev1 uncovered underscores xlalphas
Tagcloud (Intersection) ?		eif4g