EIF4E and EN2

Number of citations of the paper that reports this interaction (PubMedID 15247416)
62

Data Source:
BioGRID (pull down)

		EIF4E	EN2
Description		eukaryotic translation initiation factor 4E	engrailed homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Nuclear Body Nuclear Speck Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle MRNA Transport Nuclear Export Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Dopaminergic Neuron Differentiation Embryonic Brain Development
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs		7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate	N-cyclohexyltaurine
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)	Cytomegalovirus pp28 antibody levels ( 33204752) HDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483)
Interacting Genes		38 interacting genes: ACVRL1 APP BIRC2 CD83 CEBPA CPEB1 CYFIP1 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 EN2 GEMIN5 HOXA9 IPO8 KANK2 LRPPRC MAPKAPK5 MKNK1 MKNK2 OTX2 PML PRDM4 PRKCA PRKCB PRKCG PTEN RNMT TDO2 TLX1 TRIM27 UBXN11 XPO1	2 interacting genes: EIF4E FOXA2
Entrez ID		1977	2020
HPRD ID		00591	08836
Ensembl ID		ENSG00000151247	ENSG00000164778
Uniprot IDs		D6RBW1 P06730 Q32Q75 X5D7E3	P19622
PDB IDs		1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML 7D6Y 7D8B 7EZW 7F07 7MEU 7XTP 8QM4 8QM5 8QM6 8QM7 8QM8 8QM9 8SX4 9DON
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Eukaryotic Initiation Factor 4E Binding Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translational Initiation Negative Regulation Of Translation Negative Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Translation Repressor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Translation Factor Activity, RNA Binding Positive Regulation Of Biosynthetic Process Calcium-dependent Protein Serine/threonine Kinase Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Translation Negative Regulation Of Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translational Initiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Translation Initiation Factor Activity PML Body Histone H3T6 Kinase Activity Cognition Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Cell Cycle Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Learning Or Memory Translational Initiation	Eukaryotic Initiation Factor 4G Binding Neuron Differentiation MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Negative Regulation Of Cell Differentiation Eukaryotic Translation Initiation Factor 4F Complex Primitive Streak Formation Positive Regulation Of Gastrulation Regulation Of Gastrulation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Endocrine Pancreas Development Positive Regulation Of Embryonic Development Response To Interleukin-6 Negative Regulation Of Developmental Process Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Dopaminergic Neuron Differentiation Fear Response Response To Dexamethasone Negative Regulation Of Epithelial To Mesenchymal Transition Translation Initiation Factor Activity RNA Export From Nucleus Cell Cycle G1/S Phase Transition Cellular Response To Steroid Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cytoplasmic Ribonucleoprotein Granule Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus MRNA Export From Nucleus Multicellular Organismal Response To Stress Translational Initiation Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Adult Locomotory Behavior Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Embryonic Development Cell Fate Specification RISC Complex Cytoplasmic Stress Granule
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