GORASP2 and NUDT5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GORASP2	NUDT5
Description		golgi reassembly stacking protein 2	nudix hydrolase 5
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding RNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity ADP-sugar Diphosphatase Activity SnoRNA Binding Identical Protein Binding Protein Homodimerization Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding ADP-ribose Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Response To Unfolded Protein Organelle Organization Golgi Organization Spermatogenesis Cell Differentiation Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Plasma Membrane Organelle Assembly	Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Ribonucleoside Diphosphate Catabolic Process D-ribose Catabolic Process Ribose Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process ATP Generation From Poly-ADP-D-ribose
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization	Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS		Autism spectrum disorder ( 34069769) Cognitive performance ( 19734545)	Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		144 interacting genes: - AAMDC ACY3 ALKBH4 APIP APP ARHGEF15 ARL6IP1 ASMTL ATP6V1G1 ATXN1L BEND5 BLZF1 BTBD3 C1orf94 C21orf91 CARHSP1 CBLB CBY1 CCDC90B CDA CDC23 CDK18 CDKN2D CEP76 CGGBP1 CHMP1A CNTNAP2 CRYAA CRYAB DCTD DMC1 DNAJB13 DPYSL2 DRC12 DUSP21 DUSP4 DYRK3 ECHDC1 EIF2B1 EMILIN3 ENOX1 ENOX2 ETHE1 FIG4 GABPB2 GNG7 GNGT1 GOLGA2 GOLGA6L2 GRIK1 GSTZ1 GTF2IRD1 HOXC5 HSBP1 IFT25 JADE2 KCTD13 KCTD5 KCTD7 KCTD9 KIFC3 KRTAP5-11 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MATN4 MID2 MIEN1 MIF MORN2 MPLKIP MSC MYOM3 NCOA5 NHSL2 NME1 NMNAT1 NQO2 NUDT5 NUP62 ODC1 OGT PCBD1 PDE9A PNMA5 PRDX3 PRKAB2 PRPS1 PRRC2A PSMA3 PSMD6 RAB1A RAB27B RAB2A RAB39A RAD54B RBM46 REEP6 RGL2 RGS3 RPIA RPS6KA1 SCAND1 SELENBP1 SEPTIN1 SEPTIN14 SHMT1 STOX1 TAGLN TCF4 TEKT3 TGFA TLE5 TMED2 TMED3 TP53RK TPH1 TRAF1 TRAF2 TRAF4 TRAF5 TRAPPC6A TRIM38 TRPT1 TSC22D1 TSC22D4 TSEN15 TSN TTC19 TXLNA UBE2Z UBL3 VPS37B VPS52 XPNPEP1 ZBED1 ZBTB14 ZMAT1 ZMYND19 ZNF148	5 interacting genes: COX5B GORASP2 MAPK6 MCM3AP NUDT3
Entrez ID		26003	11164
HPRD ID		08303	14851
Ensembl ID		ENSG00000115806	ENSG00000165609
Uniprot IDs		Q9H8Y8	Q9UKK9
PDB IDs		3RLE 4EDJ	2DSB 2DSC 2DSD 3AC9 3ACA 3BM4 3L85 5NQR 5NWH 5QJ4 5QJ5 5QJ6 5QJ7 5QJ8 5QJ9 5QJA 5QJB 5QJC 5QJD 5QJE 5QJF 5QJG 5QJH 5QJI 5QJJ 5QJK 5QJL 5QJM 5QJN 5QJO 5QJP 5QJQ 5QJR 5QJS 5QJT 5QJU 5QJV 5QJW 5QJX 5QJY 5QJZ 5QK0 5QK1 5QK2 5QK3 5QK4 5QK5 5QK6 5QK7 5QK8 5QK9 5QKA 5QKB 5QTL 5QTM 5QTN 5QTO 5QTP 5QTQ 5QTR 5QTS 6GRU 8PTT 8RDZ 8RIY
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytosol Thioesterase Binding Pyrimidine-containing Compound Metabolic Process Protein Homooligomerization Cytoplasm Pyrimidine Nucleotide Biosynthetic Process Protein Complex Oligomerization Pyrimidine-containing Compound Biosynthetic Process Stress-activated MAPK Cascade Protein-containing Complex Organization Pyrimidine Nucleotide Metabolic Process Stress-activated Protein Kinase Signaling Cascade Cytosine Metabolic Process Golgi Organization Ultradian Rhythm Regulation Of Programmed Cell Death Protein-containing Complex Assembly Tumor Necrosis Factor Receptor Binding PTB Domain Binding Negative Regulation Of Programmed Cell Death D-ribose Metabolic Process MAP Kinase Activity Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process ATP Generation From Poly-ADP-D-ribose Nucleoside Monophosphate Biosynthetic Process	Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Pro-T Cell Differentiation Parathyroid Hormone Secretion Septin Cytoskeleton 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Nephric Duct Formation Regulation Of Thyroid Hormone Generation Positive Regulation Of Ureteric Bud Formation Ureter Maturation Positive Regulation Of Thyroid Hormone Generation Mast Cell Differentiation Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Ureteric Bud Formation Interleukin-2 Receptor Binding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Kidney Development Immune System Development Transcription Export Complex 2 Parathyroid Gland Development Mesonephric Tubule Formation Ureter Morphogenesis Otic Vesicle Development Nephric Duct Morphogenesis Norepinephrine Biosynthetic Process Histone H3 Acetyltransferase Activity T-helper 2 Cell Differentiation Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Epithelial Tube Formation Cellular Response To Interferon-alpha 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytochrome-c Oxidase Activity Positive Regulation Of Transcription Regulatory Region DNA Binding
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