GORASP2 and PRPS1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GORASP2	PRPS1
Gene Name		golgi reassembly stacking protein 2, 55kDa	phosphoribosyl pyrophosphate synthetase 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Organelle Organization	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process
Pathways		Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase	5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		69 interactors: AAMDC ACY3 AES APP ARL6IP1 ATXN1L BEND5 BLZF1 C1orf94 CBLB CCDC153 CDC23 CRYAA DCTD DMC1 DPYSL2 DUSP21 EIF2B1 ENOX1 GABPB2 GOLGA2 JADE2 KCTD5 KCTD9 KIFC3 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MID2 MIF MORN2 NME1 NQO2 NUP62 ODC1 PCBD1 PDE9A PNMA5 PRDX3 PRPS1 PRRC2A PSMA3 RAB1A RAB2A RAD54B RGS3 RPIA SCAND1 SELENBP1 STOX1 TCF4 TEKT3 TGFA TMED10 TMED2 TMED3 TRAF1 TRAF2 TRAF4 TRAF5 TRIM38 TSC22D4 TXLNA ZBTB14 ZMAT1 ZNF148	5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4
Entrez ID		26003	5631
HPRD ID		08303	02413
Ensembl ID		ENSG00000115806	ENSG00000147224
Uniprot IDs		B4DKT0 B4DNR1 Q9H8Y8	B7ZB02 P60891
PDB IDs		3RLE 4EDJ	2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Binding Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Golgi Organization Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of MAP Kinase Activity Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cargo Loading Into Vesicle Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Protein Transport Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Establishment Of Protein Localization Intracellular Protein Transport Regulation Of Protein Homodimerization Activity Regulation Of MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway COPII-coated Vesicle Budding Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor 3 Signaling Pathway Establishment Of Localization In Cell Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Protein Complex Assembly Positive Regulation Of Protein Metabolic Process Protein Homooligomerization Toll-like Receptor 4 Signaling Pathway Cell Death Death Positive Regulation Of Protein Serine/threonine Kinase Activity Protein Localization Positive Regulation Of Transferase Activity Cellular Localization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Protein Ubiquitination Intracellular Transport Negative Regulation Of Programmed Cell Death Negative Regulation Of Transferase Activity Protein Oligomerization Endomembrane System Organization Cell Cycle Cellular Protein Localization	5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process
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