F8 and F9

Number of citations of the paper that reports this interaction (PubMedID 11278963)
0

Data Source:
HPRD (in vitro)

		F8	F9
Description		coagulation factor VIII	coagulation factor IX
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis	Proteolysis Blood Coagulation Hemostasis Zymogen Activation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Protein hydroxylation Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog alfa Von Willebrand factor human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol Rurioctocog alfa pegol	Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Venous thromboembolism ( 31676865)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2157	2158
HPRD ID		02384	02385
Ensembl ID		ENSG00000185010	ENSG00000101981
Uniprot IDs		P00451	P00740
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF0 6MF2 7K66 7KBT 7KWO 8G6I 8TY1 9D5D	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P 7AHV 8EPC 8EPH 8EPK 8OL9 9BVK 9BVR
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Calcium Ion Binding Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Quality Control Compartment ERAD Pathway Unfolded Protein Binding Serine-type Peptidase Activity Proteolysis Negative Regulation Of Blood Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Carbohydrate Binding Protein Folding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Transport Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Response To Endoplasmic Reticulum Stress Endopeptidase Activity Protein-folding Chaperone Binding Fibrinolysis Establishment Of Protein Localization D-mannose Binding Protein Catabolic Process Regulation Of Wound Healing External Side Of Plasma Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Extracellular Space Endoplasmic Reticulum Membrane Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Extracellular Exosome Regulation Of Response To Wounding Extracellular Matrix Vesicle-mediated Transport Peptidase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity 2-oxobutyrate Catabolic Process	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Positive Regulation Of Blood Coagulation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Coagulation Acute-phase Response Protein Maturation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Hemostasis Regulation Of Blood Coagulation Endopeptidase Activity Response To Astaxanthin Gamma-glutamyl Carboxylase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Calcium Ion Binding Serine-type Peptidase Activity Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Wound Healing Serine-type Endopeptidase Activity Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Negative Regulation Of Testosterone Biosynthetic Process Lipoprotein Particle Receptor Binding Regulation Of Response To Wounding Thrombospondin Receptor Activity Response To Genistein Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neutrophil-mediated Killing Of Gram-negative Bacterium Response To Thyroxine Response To Vitamin K Response To Hydroxyisoflavone Positive Regulation Of Lysosomal Protein Catabolic Process Response To L-phenylalanine Derivative Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Phenylpropanoid Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process
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