F8 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 15886209)
0

Data Source:
HPRD (in vitro)

		F8	MCFD2
Description		coagulation factor VIII	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis	Gene Expression Protein Transport Vesicle-mediated Transport
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog alfa Von Willebrand factor human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol Rurioctocog alfa pegol	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Combined deficiency of factors V and VIII (F5F8D)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		2157	90411
HPRD ID		02384	09693
Ensembl ID		ENSG00000185010	ENSG00000180398
Uniprot IDs		P00451	B4DF17 Q8NI22
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF0 6MF2 7K66 7KBT 7KWO 8G6I 8TY1 9D5D	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Calcium Ion Binding Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Quality Control Compartment ERAD Pathway Unfolded Protein Binding Serine-type Peptidase Activity Proteolysis Negative Regulation Of Blood Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Carbohydrate Binding Protein Folding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Transport Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Response To Endoplasmic Reticulum Stress Endopeptidase Activity Protein-folding Chaperone Binding Fibrinolysis Establishment Of Protein Localization D-mannose Binding Protein Catabolic Process Regulation Of Wound Healing External Side Of Plasma Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Extracellular Space Endoplasmic Reticulum Membrane Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Extracellular Exosome Regulation Of Response To Wounding Extracellular Matrix Vesicle-mediated Transport Peptidase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity 2-oxobutyrate Catabolic Process	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway COPII-coated ER To Golgi Transport Vesicle G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Golgi Lumen Platelet Alpha Granule Lumen Regulation Of Type II Interferon Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Coagulation Blood Coagulation Hemostasis Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane G Protein-coupled UTP Receptor Activity G Protein-coupled ADP Receptor Activity Chloride Transport Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Stearoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Intermediate-density Lipoprotein Particle
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