F8 and CALR

Number of citations of the paper that reports this interaction (PMID 9525969)
16

Data Source:
HPRD (in vivo)

		F8	CALR
Gene Name		coagulation factor VIII, procoagulant component	calreticulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen	Acrosomal Vesicle Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Sarcoplasmic Reticulum Lumen MHC Class I Peptide Loading Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity	Complement Component C1q Binding Glycoprotein Binding DNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Poly(A) RNA Binding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Platelet Degranulation Proteolysis Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein N-linked Glycosylation Via Asparagine Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Regulation Of Meiosis Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Chaperone-mediated Protein Folding Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Common Pathway Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Scavenging by Class F Receptors Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Scavenging by Class A Receptors Assembly of Viral Components at the Budding Site ATF6-alpha activates chaperones Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ATF6-alpha activates chaperone genes Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Drotrecogin alfa Coagulation Factor IX
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Red blood cell traits ( 23446634)	Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 UBQLN1 VWF	39 interactors: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 SCARF1 SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TSHR UPF2 VWF
Entrez ID		2157	811
HPRD ID		02384	00169
Ensembl ID		ENSG00000185010	ENSG00000179218
Uniprot IDs		P00451	P27797
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV	2CLR 3DOW 3POS 3POW
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Regulation Of Body Fluid Levels Wound Healing Peptidyl-amino Acid Modification Vesicle-mediated Transport Response To Wounding Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Protein Activation Cascade Negative Regulation Of Blood Coagulation Platelet Activation Negative Regulation Of Coagulation Glycoprotein Metabolic Process Negative Regulation Of Wound Healing Response To Stress Platelet Degranulation Regulation Of Blood Coagulation Protein Glycosylation Macromolecule Glycosylation Glycosylation Cellular Protein Modification Process Receptor-mediated Endocytosis Regulation Of Wound Healing Cellular Protein Metabolic Process Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Response To Endoplasmic Reticulum Stress Fibrinolysis Secretion By Cell Proteolysis Transport Leukocyte Migration Cellular Localization Regulation Of Cell Migration Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of Cell Motility Chaperone-mediated Protein Folding Secretion Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Endocytosis	Response To Stimulus Response To Stress Platelet Degranulation Blood Coagulation Hemostasis Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Wound Healing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cell Activation Response To Wounding Platelet Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Exocytosis Response To External Stimulus Cellular Response To Stimulus Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I System Development Secretion By Cell Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Cell Communication Immune Response Behavior Positive Regulation Of Leukocyte Mediated Cytotoxicity Transport Secretion Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Protection From Natural Killer Cell Mediated Cytotoxicity Signaling Multicellular Organismal Development Signal Transduction Negative Regulation Of Signaling Cell Adhesion Response To Hormone Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Anatomical Structure Development Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Organic Substance
Tagcloud ?		absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Difference) ?		absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Intersection) ?