WDR5 and MBIP

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		WDR5	MBIP
Gene Name		WD repeat domain 5	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytoplasm
	Molecular Function	Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development Chromatin Organization Transcription, DNA-templated Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Histone H3-K4 Methylation	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Chromatin Organization Histone H3 Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		23 interactors: APP ATN1 CHD8 HIST1H1C HIST4H4 HSF2 IKBKG KMT2A KMT2B KMT2C MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SETD1A SETD1B SRPK2 SSX2IP TERF2IP TP53 ZXDC	41 interactors: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 CSRP2BP DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		11091	51562
HPRD ID		10614	14368
Ensembl ID		ENSG00000196363	ENSG00000151332
Uniprot IDs		P61964	B2RCV0 Q9NS73
PDB IDs		2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4IA9
Enriched GO Terms of Interacting Partners?		Gene Expression Chromatin Organization Regulation Of RNA Metabolic Process Chromosome Organization RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Histone H3-K4 Methylation RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Methylation Histone Modification Chromatin Modification Cellular Nitrogen Compound Metabolic Process Protein Methylation Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Methylation Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Chromosome Organization Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Cellular Metabolic Process Histone H3-K4 Trimethylation DNA Conformation Change Regulation Of Organelle Organization Cellular Copper Ion Homeostasis Regulation Of Fibroblast Apoptotic Process	Organelle Organization Membrane Organization Histone H3 Acetylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Phosphorylation Histone Acetylation Establishment Of Localization In Cell Cellular Localization G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Establishment Of Endothelial Barrier Mitotic Cell Cycle Internal Protein Amino Acid Acetylation Secretion By Cell Protein Acetylation Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Exocyst Assembly Intermediate Filament-based Process Exocytosis Chromatin Modification Axon Cargo Transport Endothelial Cell Development
Tagcloud ?		acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad	advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility
Tagcloud (Difference) ?		acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad	advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility
Tagcloud (Intersection) ?