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DNAJC3 and TIRAP
Number of citations of the paper that reports this interaction (PubMedID
11526399
)
0
Data Source:
HPRD
(in vivo)
DNAJC3
TIRAP
Description
DnaJ heat shock protein family (Hsp40) member C3
TIR domain containing adaptor protein
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Cytosol
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Extracellular Vesicle
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Membrane
Endocytic Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Molecular Function
Protein Kinase Inhibitor Activity
Protein Kinase Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Molecular Adaptor Activity
Biological Process
Regulation Of Translation
Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Apoptotic Process
Proteolysis Involved In Protein Catabolic Process
Defense Response To Virus
Cellular Response To Cold
Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Viral mRNA Translation
XBP1(S) activates chaperone genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation
PKR-mediated signaling
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Drugs
Diseases
GWAS
Body mass index (
28552196
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
8 interacting genes:
DNAJB1
EIF2AK2
EIF2AK3
HSPA1A
OGT
THAP12
TIRAP
UBC
25 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
Entrez ID
5611
114609
HPRD ID
03114
05878
Ensembl ID
ENSG00000102580
ENSG00000150455
Uniprot IDs
A8KA82
Q13217
P58753
PDB IDs
2Y4T
2Y4U
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
8JZM
Enriched GO Terms of Interacting Partners
?
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Inclusion Body Assembly
Response To Unfolded Protein
Regulation Of Translational Initiation
Misfolded Protein Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Inclusion Body Assembly
Response To Temperature Stimulus
Positive Regulation Of Cytokine Production
Regulation Of Cellular Response To Stress
Negative Regulation Of Translation
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Gene Expression
Response To Stress
Negative Regulation Of Protein Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Transcription Regulator Inhibitor Activity
Cellular Response To Nutrient Levels
Negative Regulation Of Translational Initiation
Cellular Response To Heat
Positive Regulation Of Pattern Recognition Receptor Signaling Pathway
Protein Folding Chaperone
Positive Regulation Of Interleukin-8 Production
Regulation Of Cytokine Production
Cellular Response To Amino Acid Starvation
Response To Amino Acid Starvation
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Interleukin-15 Production
Cellular Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Chemokine Production
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of NF-kappaB Transcription Factor Activity
Translational Initiation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Response To Heat
Regulation Of Interleukin-8 Production
Negative Regulation Of Metabolic Process
Negative Regulation Of Post-translational Protein Modification
Regulation Of Response To Endoplasmic Reticulum Stress
Denatured Protein Binding
Regulation Of Translation
Regulation Of Chemokine Production
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Chemokine Production
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Defense Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Chemokine Production
Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Defense Response
Innate Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Cytokine Production
Response To Other Organism
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Intracellular Signal Transduction
Immune Response
Defense Response To Symbiont
Defense Response To Virus
Defense Response To Other Organism
Interleukin-33-mediated Signaling Pathway
Immune System Process
Interleukin-1-mediated Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Immune System Process
Response To External Biotic Stimulus
Response To Stress
Regulation Of Type I Interferon Production
Positive Regulation Of Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Interleukin-6 Production
Response To Virus
MyD88-independent Toll-like Receptor Signaling Pathway
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