DNAJC3 and PRKRIR

Number of citations of the paper that reports this interaction (PMID 9447982)
20

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		DNAJC3	PRKRIR
Gene Name		DnaJ (Hsp40) homolog, subfamily C, member 3	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Vesicle Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Protein Kinase Inhibitor Activity Chaperone Binding Misfolded Protein Binding	DNA Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus	Response To Stress Signal Transduction Negative Regulation Of Cell Proliferation
Pathways		Influenza Viral RNA Transcription and Replication IRE1alpha activates chaperones Influenza Infection Viral mRNA Translation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Influenza Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A PRKRIR TIRAP	7 interactors: DDX58 DNAJC3 EIF2AK2 EIF2S1 STK4 TACC1 TP53
Entrez ID		5611	5612
HPRD ID		03114	09567
Ensembl ID		ENSG00000102580	ENSG00000137492
Uniprot IDs		A8KA82 Q13217	O43422
PDB IDs		2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Inclusion Body Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Inclusion Body Assembly Protein Refolding Response To Stress Response To Biotic Stimulus Regulation Of Cellular Response To Heat Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Response To Organic Substance Regulation Of Chemokine Production Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Translational Initiation Negative Regulation Of Translation Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cytokine Production Cellular Response To Stress Cellular Response To Unfolded Protein Evasion Or Tolerance By Virus Of Host Immune Response Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Interaction With Host ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Heat Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Proliferation Response To External Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Stimulus Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Hematopoietic Stem Cell Differentiation Response To Other Organism Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation	ER-nucleus Signaling Pathway Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Regulation Of Translational Initiation In Response To Stress Cellular Response To Topologically Incorrect Protein Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Unfolded Protein Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Defense Response To Virus Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Regulation Of Kinase Activity Response To Virus Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Immune System Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Translational Initiation Response To Organic Substance Regulation Of Defense Response To Virus Evasion Or Tolerance By Virus Of Host Immune Response Viral Process Regulation Of Apoptotic Process Regulation Of Stem Cell Proliferation Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Negative Regulation Of Macromitophagy Regulation Of Hematopoietic Stem Cell Differentiation Oligodendrocyte Apoptotic Process Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Helicase Activity RIG-I Signaling Pathway
Tagcloud ?		atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Difference) ?		atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Intersection) ?