ASRGL1

Description		asparaginase and isoaspartyl peptidase 1
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol
	Molecular Function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Peptidase Activity Beta-aspartyl-peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis L-asparagine Catabolic Process Via L-aspartate
Pathways		Phenylalanine metabolism
Drugs		Aspartic acid Asparagine
Diseases
GWAS		Body fat mass ( 28552196) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549) Serum metabolite levels ( 33031748) Trunk fat mass ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: ERBB2 GSK3B MAP2K5 MAPK8IP2 TAB1
Entrez ID		80150
HPRD ID		07006
Ensembl ID		ENSG00000162174
Uniprot IDs		A0A024R573 Q7L266
PDB IDs		3TKJ 4ET0 4O0C 4O0D 4O0E 4O0F 4O0G 4O0H 4OSX 4OSY 4PVP 4PVQ 4PVR 4PVS 4ZM9
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Growth Regulation Of Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication ERBB3:ERBB2 Complex Regulation Of Growth Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity ERK5 Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Translation RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation
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