TERT and PDGFRA

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TERT	PDGFRA
Description		telomerase reverse transcriptase	platelet derived growth factor receptor alpha
Image
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Protein-containing Complex Cell Projection Receptor Complex Platelet-derived Growth Factor Receptor-ligand Complex
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance RNA-templated Transcription RNA-templated DNA Biosynthetic Process Protein Import Into Nucleus Telomere Maintenance Via Telomerase Mitochondrion Organization Heart Development DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway SiRNA Processing Regulation Of Protein Stability Positive Regulation Of Hair Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of D-glucose Import Response To Cadmium Ion Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence SiRNA Transcription Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of Transdifferentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Female Gonad Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Platelet Activation Cell Migration Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Regulation Of Actin Cytoskeleton Organization Leydig Cell Differentiation Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Calcium-mediated Signaling White Fat Cell Differentiation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Zidovudine Grn163l Tertomotide	Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Tivozanib Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases		Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome	Glioma
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 19151717 24403052 25855136 31174203 33549134) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 20972438 24163127) Breast cancer ( 22037553 23535729 23535733 27117709 28171663 29059683) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 26956414 28165464) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 19578367 21531791 21827660 22886559 28346443 29743610 30714141) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 18835860 31710517) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 19836008 20700438 20871597 22797724 27393504 28604730) Lung cancer ( 18978790 21725308 23143601 27393504 31577861) Lung cancer in never smokers ( 28604730 31009812) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 27863252 28017375 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 26545403 27436580) Neutrophil count ( 27863252 29403010 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 25086665 27579533 29422604) Platelet count ( 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 21743467 25939597 31562322) Prostate-specific antigen levels ( 28139693 30410027) Red blood cell count ( 20139978 27863252 29403010 32888494) Serum prostate-specific antigen levels ( 21160077) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 27863252 29403010 32888494)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 29422769 22144915) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 28453575 29403010 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		81 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 PTPA RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP USP7 XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	62 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR ERBB2 ERBB3 FBXO25 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 NHERF1 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		7015	5156
HPRD ID		01754	01429
Ensembl ID		ENSG00000164362	ENSG00000134853
Uniprot IDs		O14746	P16234
PDB IDs		2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW 7BG9 7QXA 7QXB 7QXS 7TRD 7TRE 7TRF 7V99	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 7LBF 7RAM 8PQH 8PQI 8PQJ 8PQK 9GZH
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Cellular Response To Stress Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Activity ATP Binding Regulation Of Chromosome Organization Telomere Maintenance Kinase Activity Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Regulation Of Organelle Organization Organelle Organization Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Nucleotide Binding Telomere Organization Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Telomere Maintenance Via Telomere Lengthening Intracellular Signaling Cassette Cytoplasm Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of DNA Biosynthetic Process Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of Signal Transduction	Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Developmental Process Cellular Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Cell Differentiation Animal Organ Development Negative Regulation Of Cell Differentiation Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Migration Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Motility Regulation Of Cell Development Response To Epidermal Growth Factor Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?