ACRV1 and PLS3

Data Source: HiPPIP (Novel)

		ACRV1	PLS3
Name		acrosomal vesicle protein 1	plastin 3
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle Vesicle	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle
	Molecular Function	Protein Binding	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton
	Biological Process	Spermatogenesis	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization
GWAS		Breast cancer (survival) ( 25890600 ) Platelet count ( 32888494 )	Gestational age at birth (maternal effect) ( 28877031 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Preterm birth (maternal effect) ( 28877031 )
Novel Interactors		2 novel interactors: PLS3 UPF1	14 novel interactors: ACRV1 ASGR1 CUL4B CXCR5 FRYL LRCH2 NRSN1 PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Interacting Genes		1 interacting genes: CFTR	5 interacting genes: APP ATXN2 FILNC1 OGT SNCA
Entrez ID		56	5358
HPRD ID		00014	02133
Ensembl ID		ENSG00000134940	ENSG00000102024
Uniprot IDs		P26436	B4DPW9 P13797
PDB IDs		Not available	1AOA 1WJO 7R94 7SX8 7SX9 7SXA
GO Terms Enriched among Interactors		Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Structural Constituent Of Presynaptic Actin Cytoskeleton Double-stranded DNA Helicase Activity Supraspliceosomal Complex Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport ATP Hydrolysis Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Regulation Of Translational Termination Telomere Maintenance Via Semi-conservative Replication Amelogenesis Actin Filament Bundle ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Cellular Response To Lipid Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin Golgi-associated Vesicle Membrane Regulation Of Synaptic Vesicle Cycle Histone MRNA Catabolic Process Response To Forskolin Regulation Of Vesicle-mediated Transport 3'-UTR-mediated MRNA Destabilization Chloride Transmembrane Transporter Activity Sperm Capacitation Exon-exon Junction Complex Bicarbonate Transport Histone MRNA Metabolic Process Water Transport Multicellular Organismal-level Water Homeostasis Telomeric DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding	Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation