GJA1 and CNST

Number of citations of the paper that reports this interaction (PMID 19864490)
10

Data Source:
BioGRID (pull down)

		GJA1	CNST
Gene Name		gap junction protein, alpha 1, 43kDa	consortin, connexin sorting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexon Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Contractile Fiber Membrane Raft Extracellular Vesicular Exosome	Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Transport Vesicle Protein Complex
	Molecular Function	Signal Transducer Activity Receptor Binding Gap Junction Channel Activity Protein Binding Ion Transmembrane Transporter Activity SH3 Domain Binding PDZ Domain Binding Beta-tubulin Binding Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Scaffold Protein Binding	Protein Binding Phosphatase Binding Connexin Binding
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Negative Regulation Of Endothelial Cell Proliferation Heart Looping Epithelial Cell Maturation Lens Development In Camera-type Eye Chronic Inflammatory Response Positive Regulation Of Glomerular Filtration Endothelium Development Atrial Ventricular Junction Remodeling Transport Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Adult Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling ATP Transport Gap Junction Assembly Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Ion Transmembrane Transport Response To Fluid Shear Stress Embryonic Digit Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Regulation Of Bone Remodeling Blood Vessel Morphogenesis Neuron Projection Morphogenesis Protein Oligomerization Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Milk Ejection Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Membrane Organization Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process Regulation Of Tight Junction Assembly Positive Regulation Of Behavioral Fear Response	Negative Regulation Of Phosphatase Activity Positive Regulation Of Golgi To Plasma Membrane Protein Transport
Pathways		c-src mediated regulation of Cx43 function and closure of gap junctions Transport of connexons to the plasma membrane Formation of annular gap junctions Gap junction assembly Transport of connexins along the secretory pathway Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Oligomerization of connexins into connexons Regulation of gap junction activity
Drugs		Carvedilol
Diseases
GWAS		Heart rate ( 23583979) Protein quantitative trait loci ( 18464913) Resting heart rate ( 23183192 20639392)
Protein-Protein Interactions		18 interactors: CAV1 CNST CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 NOV PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1	11 interactors: EWSR1 GJA1 GJB1 GJB2 GJB3 GJB6 GJC1 POT1 PPP1CA PPP1CC ROPN1
Entrez ID		2697	163882
HPRD ID		00414	08718
Ensembl ID		ENSG00000152661	ENSG00000162852
Uniprot IDs		P17302	Q6PJW8
PDB IDs		2LL2
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Wound Healing Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-serine Phosphorylation Signaling Cell Communication Response To Wounding Intracellular Signal Transduction Regulation Of Cellular Localization Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Immune System Process Protein Phosphorylation Peptidyl-amino Acid Modification Phosphorylation Cell Activation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Cell-cell Signaling Response To Growth Factor Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Regulation Of MAPK Cascade Regulation Of Protein Transport Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway	Gap Junction Assembly Cell-cell Junction Assembly Cell Junction Assembly Cell-cell Junction Organization Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Cell-cell Signaling Involved In Cardiac Conduction Response To Glucose Triglyceride Catabolic Process Sensory Perception Of Sound Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Sensory Perception Of Mechanical Stimulus Response To Carbohydrate Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Regulation Of DNA Biosynthetic Process Response To Organic Substance Sensory Perception Glycogen Metabolic Process Membrane Organization Cell Communication Cell-cell Signaling System Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA Strand Elongation Response To Human Chorionic Gonadotropin Milk Ejection Vascular Transport Regulation Of Cardiac Muscle Contraction Circadian Regulation Of Gene Expression Organ Development Polysaccharide Metabolic Process Cellular Component Assembly Action Potential Regulation Of Striated Muscle Contraction Triglyceride Metabolic Process Response To Abiotic Stimulus Regulation Of Circadian Rhythm Negative Regulation Of DNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Atrial Ventricular Junction Remodeling Positive Regulation Of Cell Communication By Chemical Coupling Multicellular Organismal Development Neutral Lipid Metabolic Process
Tagcloud ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	advance canadian completion confirms coordinators criterion dietitians doi dt ejcn exploratory item journal nutrition palliative personnel predicts publication rater readmission reliability subsample technician tool untrained validity wards x2 yes
Tagcloud (Difference) ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	advance canadian completion confirms coordinators criterion dietitians doi dt ejcn exploratory item journal nutrition palliative personnel predicts publication rater readmission reliability subsample technician tool untrained validity wards x2 yes
Tagcloud (Intersection) ?