GJA1 and CAV1

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		GJA1	CAV1
Description		gap junction protein alpha 1	caveolin 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Gap Junction Connexin Complex Focal Adhesion Intercalated Disc Membrane Apical Plasma Membrane Cell Junction Golgi-associated Vesicle Membrane Cell-cell Contact Zone Membrane Raft Tight Junction Anchoring Junction	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Gap Junction Channel Activity Protein Binding Beta-catenin Binding Monoatomic Ion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Tubulin Binding Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity Alpha-tubulin Binding Gap Junction Hemi-channel Activity Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Signaling Receptor Binding Patched Binding Protein Binding Oxysterol Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Protein Heterodimerization Activity Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity Protein Sequestering Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cardiac Conduction System Development Cell Communication Signal Transduction Cell-cell Signaling Spermatogenesis Heart Development Intracellular Protein Localization Positive Regulation Of Gene Expression Cell Communication By Electrical Coupling Glutamate Secretion Gap Junction Assembly Negative Regulation Of Cell Growth Negative Regulation Of Gonadotropin Secretion Monoatomic Ion Transmembrane Transport Glutathione Transmembrane Transport Maintenance Of Blood-brain Barrier Xenobiotic Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell-cell Junction Organization Bone Remodeling Transmembrane Transport Bone Development Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Microtubule-based Transport Positive Regulation Of Cold-induced Thermogenesis Export Across Plasma Membrane Negative Regulation Of Trophoblast Cell Migration Regulation Of Blood Circulation Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Mesodermal Cell Differentiation Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Vasculogenesis Response To Hypoxia Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Differentiation Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Nitric Oxide Biosynthetic Process Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Protein Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Maintenance Of Protein Location In Cell Response To Progesterone Intracellular Nitric Oxide Homeostasis Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin Receptor Internalization Angiotensin-activated Signaling Pathway Vasoconstriction Cholesterol Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Muscle Cell Cellular Homeostasis Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Pinocytosis Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Establishment Of Localization In Cell Membrane Depolarization Calcium Ion Homeostasis Mammary Gland Involution Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Caveola Assembly Cellular Response To Misfolded Protein Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Positive Regulation Of ERAD Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions RHOQ GTPase cycle RHOJ GTPase cycle SARS-CoV-2 targets PDZ proteins in cell-cell junction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Thyroxine biosynthesis Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle FOXO-mediated transcription of cell cycle genes RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Carvedilol
Diseases		Deafness, autosomal recessive Oculodentodigital dysplasia Syndactyly	Congenital generalized lipodystrophy (CGL)
GWAS		Atrial fibrillation ( 29892015 28416822 28416818) Disease progression in age-related macular degeneration ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Focal epilepsy (with hippocampal sclerosis) ( 30531953) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heart rate ( 23583979) Heel bone mineral density ( 30598549) Migraine ( 27322543) Peak creatinine levels in vancomycin therapy ( 26030142) PR interval ( 32439900) Protein quantitative trait loci ( 18464913) Pulse pressure ( 27841878 28135244) Resting heart rate ( 20639392 29769521 23183192 27798624) RR interval (heart rate) ( 30679814) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Tendinopathy ( 31615970) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Atrial fibrillation ( 33990960 22544366 30061737 29892015 28416822) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 25173105 29891935 33627673 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29235454 25173106 28073927 29617998) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494) PR interval ( 20062060 25035420 32439900 30679814 23139255 30046033 29127183) PR segment duration ( 24850809) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QRS duration ( 30012220) QT interval ( 29874175 24952745) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		29 interacting genes: AKT1 CAV1 CCN3 CNST CREB3 CSK CSNK1D GABARAP GJA3 GJA5 HTR2C ITCH MAPK1 MAPK3 MAPK7 NEDD4 NINJ2 PLPP4 PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1 TMEM128 TMEM86B UBQLN4	86 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DANCR DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF4 TRAF6 TRPC1 USP7 VAV2
Entrez ID		2697	857
HPRD ID		00414	03028
Ensembl ID		ENSG00000152661	ENSG00000105974
Uniprot IDs		P17302	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		2LL2 7F92 7F93 7F94 7XQ9 7XQB 7XQD 7XQF 7XQG 7XQH 7XQI 7XQJ 7Z1T 7Z22 7Z23 8QKO	7SC0
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Protein Catabolic Process Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Gap Junction Regulation Of Vesicle-mediated Transport Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Phosphorylation Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Regulation Of Proteolysis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signaling Negative Regulation Of Transport Positive Regulation Of Locomotion Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Plasma Membrane Response To Peptide Hormone Regulation Of Immune System Process Response To Growth Factor Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette	Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Membrane Raft Regulation Of Cellular Component Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Biological Quality Kinase Activity Protein Phosphorylation Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Membrane Anatomical Structure Morphogenesis Phosphorylation Receptor Complex Regulation Of ERK1 And ERK2 Cascade
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