GJA1 and CAV1

Number of citations of the paper that reports this interaction (PMID 11980479)
46

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		GJA1	CAV1
Gene Name		gap junction protein, alpha 1, 43kDa	caveolin 1, caveolae protein, 22kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexon Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Contractile Fiber Membrane Raft Extracellular Vesicular Exosome	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Receptor Binding Gap Junction Channel Activity Protein Binding Ion Transmembrane Transporter Activity SH3 Domain Binding PDZ Domain Binding Beta-tubulin Binding Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Scaffold Protein Binding	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Negative Regulation Of Endothelial Cell Proliferation Heart Looping Epithelial Cell Maturation Lens Development In Camera-type Eye Chronic Inflammatory Response Positive Regulation Of Glomerular Filtration Endothelium Development Atrial Ventricular Junction Remodeling Transport Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Adult Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling ATP Transport Gap Junction Assembly Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Ion Transmembrane Transport Response To Fluid Shear Stress Embryonic Digit Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Regulation Of Bone Remodeling Blood Vessel Morphogenesis Neuron Projection Morphogenesis Protein Oligomerization Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Milk Ejection Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Membrane Organization Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process Regulation Of Tight Junction Assembly Positive Regulation Of Behavioral Fear Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		c-src mediated regulation of Cx43 function and closure of gap junctions Transport of connexons to the plasma membrane Formation of annular gap junctions Gap junction assembly Transport of connexins along the secretory pathway Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Oligomerization of connexins into connexons Regulation of gap junction activity	Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer
Drugs		Carvedilol
Diseases
GWAS		Heart rate ( 23583979) Protein quantitative trait loci ( 18464913) Resting heart rate ( 23183192 20639392)	Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)
Protein-Protein Interactions		18 interactors: CAV1 CNST CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 NOV PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1	81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP
Entrez ID		2697	857
HPRD ID		00414	03028
Ensembl ID		ENSG00000152661	ENSG00000105974
Uniprot IDs		P17302	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		2LL2
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Wound Healing Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-serine Phosphorylation Signaling Cell Communication Response To Wounding Intracellular Signal Transduction Regulation Of Cellular Localization Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Immune System Process Protein Phosphorylation Peptidyl-amino Acid Modification Phosphorylation Cell Activation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Cell-cell Signaling Response To Growth Factor Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Regulation Of MAPK Cascade Regulation Of Protein Transport Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
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