GJA1 and GJA3

Number of citations of the paper that reports this interaction (PMID 11739633)
16

Data Source:
HPRD (in vivo)

		GJA1	GJA3
Gene Name		gap junction protein, alpha 1, 43kDa	gap junction protein, alpha 3, 46kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexon Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Contractile Fiber Membrane Raft Extracellular Vesicular Exosome	Connexon Complex Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Receptor Binding Gap Junction Channel Activity Protein Binding Ion Transmembrane Transporter Activity SH3 Domain Binding PDZ Domain Binding Beta-tubulin Binding Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Scaffold Protein Binding	Gap Junction Channel Activity
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Negative Regulation Of Endothelial Cell Proliferation Heart Looping Epithelial Cell Maturation Lens Development In Camera-type Eye Chronic Inflammatory Response Positive Regulation Of Glomerular Filtration Endothelium Development Atrial Ventricular Junction Remodeling Transport Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Adult Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling ATP Transport Gap Junction Assembly Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Ion Transmembrane Transport Response To Fluid Shear Stress Embryonic Digit Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Regulation Of Bone Remodeling Blood Vessel Morphogenesis Neuron Projection Morphogenesis Protein Oligomerization Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Milk Ejection Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Membrane Organization Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process Regulation Of Tight Junction Assembly Positive Regulation Of Behavioral Fear Response	Transport Cell-cell Signaling Visual Perception Transmembrane Transport
Pathways		c-src mediated regulation of Cx43 function and closure of gap junctions Transport of connexons to the plasma membrane Formation of annular gap junctions Gap junction assembly Transport of connexins along the secretory pathway Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Oligomerization of connexins into connexons Regulation of gap junction activity	Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs		Carvedilol
Diseases
GWAS		Heart rate ( 23583979) Protein quantitative trait loci ( 18464913) Resting heart rate ( 23183192 20639392)
Protein-Protein Interactions		18 interactors: CAV1 CNST CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 NOV PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1	5 interactors: CAV1 GJA1 MIP PRKCG TJP1
Entrez ID		2697	2700
HPRD ID		00414	00415
Ensembl ID		ENSG00000152661	ENSG00000121743
Uniprot IDs		P17302	Q9Y6H8
PDB IDs		2LL2
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Wound Healing Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-serine Phosphorylation Signaling Cell Communication Response To Wounding Intracellular Signal Transduction Regulation Of Cellular Localization Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Immune System Process Protein Phosphorylation Peptidyl-amino Acid Modification Phosphorylation Cell Activation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Cell-cell Signaling Response To Growth Factor Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Regulation Of MAPK Cascade Regulation Of Protein Transport Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway	Cellular Chemical Homeostasis Cellular Homeostasis Regulation Of Membrane Repolarization Chemical Homeostasis Positive Regulation Of Vasoconstriction Negative Regulation Of Endothelial Cell Proliferation Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Homeostatic Process Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Contraction Regulation Of Endothelial Cell Proliferation Regulation Of Striated Muscle Contraction Regulation Of Body Fluid Levels Endothelium Development Wound Healing Lens Development In Camera-type Eye Negative Regulation Of Protein Ubiquitination Cell-cell Signaling Involved In Cell-cell Junction Organization Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Mismatch Repair Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Milk Ejection Vascular Transport Tissue Remodeling Response To Wounding Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Response To Glucose Multicellular Organismal Development Anatomical Structure Development Regulation Of Mismatch Repair Positive Regulation Of Cell Communication By Chemical Coupling Nitric Oxide Homeostasis Atrial Ventricular Junction Remodeling Regulation Of Muscle Contraction Membrane Organization Regulation Of Ion Homeostasis Regulation Of Heart Contraction Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Response To Organic Substance Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Response To Carbohydrate Regulation Of Calcium Ion Transport Apoptotic Process Developmental Process
Tagcloud ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	aiims beaded bfsp1 cataract congenital cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Difference) ?		14days 1mg 3days alters anthracene antral connexin cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	aiims beaded bfsp1 cataract congenital cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin d85n delhi e155k e75k expands filament fourteen gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Intersection) ?		cx