GJA1 and GJA5

Number of citations of the paper that reports this interaction (PMID 11557558)
34

Data Source:
HPRD (in vivo)

		GJA1	GJA5
Gene Name		gap junction protein, alpha 1, 43kDa	gap junction protein, alpha 5, 40kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexon Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Contractile Fiber Membrane Raft Extracellular Vesicular Exosome	Integral Component Of Plasma Membrane Gap Junction Connexon Complex Intercalated Disc Cell Projection
	Molecular Function	Signal Transducer Activity Receptor Binding Gap Junction Channel Activity Protein Binding Ion Transmembrane Transporter Activity SH3 Domain Binding PDZ Domain Binding Beta-tubulin Binding Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Scaffold Protein Binding	Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Negative Regulation Of Endothelial Cell Proliferation Heart Looping Epithelial Cell Maturation Lens Development In Camera-type Eye Chronic Inflammatory Response Positive Regulation Of Glomerular Filtration Endothelium Development Atrial Ventricular Junction Remodeling Transport Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Adult Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling ATP Transport Gap Junction Assembly Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Ion Transmembrane Transport Response To Fluid Shear Stress Embryonic Digit Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Regulation Of Bone Remodeling Blood Vessel Morphogenesis Neuron Projection Morphogenesis Protein Oligomerization Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Milk Ejection Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Membrane Organization Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process Regulation Of Tight Junction Assembly Positive Regulation Of Behavioral Fear Response	Skeletal System Development Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication By Chemical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Artery Morphogenesis Protein Oligomerization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion
Pathways		c-src mediated regulation of Cx43 function and closure of gap junctions Transport of connexons to the plasma membrane Formation of annular gap junctions Gap junction assembly Transport of connexins along the secretory pathway Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Oligomerization of connexins into connexons Regulation of gap junction activity	Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs		Carvedilol
Diseases
GWAS		Heart rate ( 23583979) Protein quantitative trait loci ( 18464913) Resting heart rate ( 23183192 20639392)	Cognitive performance ( 20125193)
Protein-Protein Interactions		18 interactors: CAV1 CNST CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 NOV PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1	5 interactors: AAR2 GJA1 MARK1 PRKACA RIMS3
Entrez ID		2697	2702
HPRD ID		00414	08699
Ensembl ID		ENSG00000152661	ENSG00000143140
Uniprot IDs		P17302	P36382
PDB IDs		2LL2
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Wound Healing Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-serine Phosphorylation Signaling Cell Communication Response To Wounding Intracellular Signal Transduction Regulation Of Cellular Localization Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Immune System Process Protein Phosphorylation Peptidyl-amino Acid Modification Phosphorylation Cell Activation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Cell-cell Signaling Response To Growth Factor Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Regulation Of MAPK Cascade Regulation Of Protein Transport Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Tight Junction Assembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cardiac Conduction Regulation Of Cell Junction Assembly Regulation Of Cardiac Muscle Contraction Regulation Of Endothelial Cell Proliferation Regulation Of Secretion Regulation Of Striated Muscle Contraction Renal System Process Cell-cell Junction Assembly Positive Regulation Of Dense Core Granule Biogenesis Milk Ejection Vascular Transport Positive Regulation Of Behavior Cell Migration Regulation Of Osteoblast Differentiation Regulation Of Wound Healing Response To Glucose Cell Motility Cell Maturation Regulation Of Muscle Contraction Regulation Of Ion Homeostasis Regulation Of Heart Contraction Neuron Migration Positive Regulation Of Cell Communication By Chemical Coupling Histone H3-T6 Phosphorylation Atrial Ventricular Junction Remodeling Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Response To Carbohydrate Regulation Of Behavior Regulation Of Calcium Ion Transport Regulation Of Ossification Regulation Of Insulin Secretion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Peptide Hormone Secretion Locomotion Cell Communication By Chemical Coupling Regulation Of Hormone Secretion Regulation Of Membrane Potential Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis ATP Transport Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Regulation Of Synaptic Transmission Peptidyl-serine Autophosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Tagcloud ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs gap gja1 inducer junction junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin
Tagcloud (Difference) ?		14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gja4 gjc1 lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks	aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs inducer junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin
Tagcloud (Intersection) ?		gap gja1 junction