TCHP and KRT8

Number of citations of the paper that reports this interaction (PMID 15731013)
9

Data Source:
HPRD (two hybrid)

		TCHP	KRT8
Gene Name		trichoplein, keratin filament binding	keratin 8, type II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Plasma Membrane Keratin Filament Apical Cortex	Nucleus Nucleoplasm Cytoplasm Intermediate Filament Cell-cell Junction Dystrophin-associated Glycoprotein Complex Nuclear Matrix Z Disc Sarcolemma Costamere Keratin Filament Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Protein Complex Binding Scaffold Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Growth	Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Sarcomere Organization Response To Hydrostatic Pressure Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Metabolite levels (MHPG) ( 23319000)	Prostate cancer ( 21743057)
Protein-Protein Interactions		21 interactors: CCDC172 CCDC85B CDR2 DYDC1 KRT14 KRT15 KRT16 KRT18 KRT40 KRT5 KRT6A KRT8 LZTS2 MIPOL1 MKRN3 NAB2 NDOR1 NME7 TEX11 TRIM27 VIM	35 interactors: ANXA1 BYSL DEDD DMD EGFR FBXO25 FGFR3 GRB2 HSPA5 IKBKG KPNA2 KRT13 KRT15 KRT17 KRT18 KRT31 KRT38 KRT40 MAPK1 MAPK14 MAPK3 MAPK8 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO1 SUMO2 SUMO3 TCHP TFIP11 TROAP
Entrez ID		84260	3856
HPRD ID		14403	01015
Ensembl ID		ENSG00000139437	ENSG00000170421
Uniprot IDs		Q9BT92	P05787 Q7L4M3
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Developmental Process Cytoskeleton Organization Anatomical Structure Development Epidermis Development Hemidesmosome Assembly Epithelium Development Organelle Organization Hepatocyte Apoptotic Process Intermediate Filament Organization Cellular Component Assembly Tumor Necrosis Factor-mediated Signaling Pathway Response To Zinc Ion Cell-substrate Junction Assembly Tissue Development Golgi To Plasma Membrane CFTR Protein Transport Cellular Response To Menadione Negative Regulation Of Interleukin-2 Secretion Organ Development Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Hair Cycle Meiotic Gene Conversion Response To Tumor Necrosis Factor Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Response To Inorganic Substance Negative Regulation Of Calcium Ion Import Male Meiosis Chromosome Segregation Intermediate Filament Bundle Assembly Cell Differentiation Response To Ionizing Radiation Cell Death Death Keratinocyte Migration Negative Regulation Of Transcription From RNA Polymerase III Promoter Epithelial Cell Differentiation Response To Hydrostatic Pressure Bergmann Glial Cell Differentiation Viral Process Interferon-gamma Secretion Chiasma Assembly	Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Tissue Development Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Positive Regulation Of Protein Metabolic Process Programmed Cell Death Innate Immune Response Cell Death Death Immune Response-regulating Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Organic Substance Positive Regulation Of Transferase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Lipid Response To Growth Factor Anatomical Structure Development Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Defense Response Developmental Process Epithelium Development Response To Abiotic Stimulus Regulation Of Immune Response Positive Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process
Tagcloud ?			ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Difference) ?			ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Intersection) ?