NCOA3 and CDKN3

Number of citations of the paper that reports this interaction (PubMedID 21577200)
70

Data Source:
BioGRID (two hybrid)

		NCOA3	CDKN3
Description		nuclear receptor coactivator 3	cyclin dependent kinase inhibitor 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity Disordered Domain Specific Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Cellular Response To Hormone Stimulus Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Cortical volume ( 32963231) Dental caries ( 23259602) Endometrial cancer (Non-endometrioid histology) ( 30093612) High myopia ( 31816047) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monobrow thickness ( 26926045) Myopia ( 27182965) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4C16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	9 interacting genes: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3 PPP1R12A ROCK2
Entrez ID		8202	1033
HPRD ID		03570	00450
Ensembl ID		ENSG00000124151	ENSG00000100526
Uniprot IDs		Q59EE8 Q9Y6Q9	G3V2J7 Q16667
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Signal Transduction Nucleoplasm Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Nucleus Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Histone Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Organizing Center Organization Mitotic Nuclear Membrane Disassembly Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of DNA Replication Nuclear Membrane Disassembly Membrane Disassembly Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Endothelial Barrier Centrosome Duplication Regulation Of Cell Cycle Phase Transition Cell Division Nuclear Envelope Organization Regulation Of Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Protein Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Keratinocyte Differentiation Kinase Activity Regulation Of Endothelial Cell Differentiation Centrosome Positive Regulation Of Cell Cycle Process Centrosome Cycle Nuclear Membrane Organization Positive Regulation Of Metabolic Process Cell Population Proliferation Positive Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Epidermal Cell Differentiation Pronuclear Fusion Cellular Response To Xenobiotic Stimulus
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